Irreversible inhibitory effect of atropine on contractile responses to drugs in isolated rabbit ileum.
スポンサーリンク
概要
- 論文の詳細を見る
Effect of atropine sulfate (atropine) on the contractile responses to acetylcholine chloride (ACh), potassium chloride (K) and barium chloride (Ba) was investigated in isolated rabbit ileum. Tension of the strips suspended in the bath medium (Locke solution, 30°C) was isotonically recorded. The K(ED50)- and Ba(ED50)-induced contractions were not affected by atropine at 3.0×10<SUP>-4</SUP> mM, which reversibly abolished the ACh(ED100)-contraction. After washout of 6.0×10<SUP>-4</SUP> mM atropine, the phasic, but not the tonic, component of ACh(ED50)-, K(ED50)- and Ba(ED50)-contractions was to some extent inhibited irreversibly. On the contrary, such irreversible inhibition of the phasic component was not produced by atropine methylbromide even in the high concentration of 3.0×10<SUP>-3</SUP> mM. The irreversible inhibitions by atropine of 6.0×10<SUP>-4</SUP> mM on the phasic component of ACh- and K-contractions were protected by pretreatment with a high concentration of ACh or K. Further, these irreversible inhibitions by atropine were potentiated by the absence of Ca and were abolished by the increase of Ca content in bath media. These results suggest that the irreversible inhibition of the contractile responses to drugs by atropine in high concentration may be due to the interference with the mobilization of Ca in the deep layer of the membrane, rather than by a blockade of muscarinic receptor sites.
- 公益社団法人 日本薬理学会の論文
著者
-
Taniyama Kohtaro
Department Of Pharmacology Nagasaki University Graduate School Of Biomedical Sciences
-
ARAKI Hiromasa
Department of Pharmacology, Kobe University School of Medicine
-
MATSUMOTO Hiroshi
Doshisha Womens College
-
Cheng Juei-Tang
Department of Medical Research, Chi Mei Medical Center
-
OGINO Kouhei
Department of Pharmacology, Kobe University School of Medicine
関連論文
- Acceleration by KW-5092 of Intestinal Motility Associated With Acetylcholine Release In Vivo
- μ-Opioid Receptor Forms a Functional Heterodimer With Cannabinoid CB_1 Receptor : Electrophysiological and FRET Assay Analysis
- Neuroprotective Effect of TTC-909, an Isocarbacyclin Methyl Ester Incorporated in Lipid Microspheres, on Hippocampal Delayed Neuronal Death of Stroke-Prone Spontaneously Hypertensive Rats
- Histologicak Evience for Neuroprotective Action of Nebracetam on Ischemic Neuronal Injury in the Hippocampus of Stroke-Prone Spontaneously Hypertensive Rats
- Inhibition by γ-Aminobutyric Acid System Activation of Epileptic Seizures in Spontaneously Epileptic Rats
- GTPγS-Induced Ca^ Activated C1^- Currents: Its Stable Induction by Gqα Overexpression in Xenopus Oocytes
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- In Vivo Assessment of Acceleration of Motor Activity Associated With Acetylcholine Release via 5-Hydroxytryptamine_4 Receptor in Dog Intestine
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- Functions of peripheral 5-hydroxytryptamine receptors, especially 5-hydroxytryptamine-4 receptor, in gastrointestinal motility
- In Vivo Microdialysis Assessment of Nerve-Stimulated Contractions Associated With Increased Acetylcholine Release in the Dog Intestine
- Propofol Inhibits Muscarinic Acetylcholine Receptor-Mediated Signal Transduction in Xenopus Oocytes Expressing the Rat M1 Receptor
- Two distinct inactivation processes related to phosphorylation in cardiac L-type Ca^ channel currents
- Inhibition by Selenium Compounds of Catecholamine Secretion Due to Inhibition of Ca^ Influx in Cultured Bovine Adrenal Chromaffin Cells
- Increases in Serum Nitrite and Nitrate of a New-Fold Adversely Affect the Outcome of Pregnancy in Rats
- Regional and Functional Differences of 5-Hydroxytryptamine-Receptor Subtypes in Guinea Pig Stomach
- Facilitation of Acetylcholine Release by SK-951, a Benzofuran Derivative, via the 5-Hydroxytryptamine_4 Receptor in Guinea Pig Stomach
- Identification of SK-951, a Novel Benzofuran Derivative, as an Agonist to 5-HT_4 Receptors
- Assessment of Novel Muscarinic Acetylcholine Receptors in Rat Cerebral Cortex by a Tissue Segment Binding Method
- Activation of a Potassium Conductance by Extracellular Alkaline pH in Oocytes of Xenopus laevis
- 5-Hydroxytryptamine Receptors, Especially the 5-HT_4 Receptor, in Guinea Pig Urinary Bladder
- MODIFICATION OF THE TONUS AND DRUG-INDUCED CONTRACTION OF THE ISOLATED RAT ILEUM BY REMOVAL OF Na FROM BATHING MEDIA
- INFLUENCES OF AMINOPHYLLINE AND REDUCTION IN EXTERNAL Na ON THE ANTISPASMODIC ACTION OF ISOPROTERENOL IN THE ISOLATED RAT RECTUM
- Role of cerebral dopamine but not plasma insulin, leptin and glucocorticoid in the development of tolerance to the anorectic effect of amphetamine
- Stimulatory effect of dopamine on acid secretion from the isolated rat stomach
- ACTIONS OF Ba AND Sr IONS ON ISOLATED RAT ILEUM
- ENZYMATIC DECARBOXYLATION OF L-THREO-3, 4-DIHYDROXYPHENYLSERINE IN RAT HEART
- Mechanism of Inhibitory Actions of Geranium thunbergii, Tannic Acid and Geraniin on the Motility of Rat Intestine
- ISO-2-4 Intraperitoneal injection of (-)-epigallocatechin-3-gallate (EGCG) increase bone mineral density in ovariectomized rats(Group 2 Reproduction/Women's Health,IS Award Candidate,International Session)
- Mechanism of contractile response to Mn ion in isolated rat rectum.
- Irreversible inhibitory effect of atropine on contractile responses to drugs in isolated rabbit ileum.
- Cyclic adenosine 3',5'-monophosphate levels in response to norepinephrine in rectum of postnatal rats.
- Effects of MPC-1304, a Novel Calcium Antagonist, on Stroke-Prone Spontaneously Hypertensive Rats
- Expression of the Endothelin Receptors in the Hippocampus of SHRSP after Transient Forebrain Ischemia
- Effects of adenosine on contractile response of circular muscle in electrically stimulated guinea-pig ileum.
- "CALCIUM-INDUCED RELEASE OF CALCIUM" IN RECTAL SMOOTH MUSCLE OF MICE