Long-Term Treatment With Perindopril Ameliorates Dobutamine-Induced Myocardial Ischemia in Patients With Coronary Artery Disease
スポンサーリンク
概要
- 論文の詳細を見る
The present study was designed to examine whether long-term blockade of angiotensin-converting enzyme (ACE) with perindopril ameliorates dobutamine-induced myocardial ischemia in patients with coronary artery disease (CAD). Twelve patients with proven CAD were randomly divided in two groups; one group received perindopril (8 mg/day, p.o.) for 3 months and another group served as a control. To evaluate anti-ischemic effects of perindopril, dobutamine stress echocardiography was performed before and 3 months after the treatment in a double-blind manner. Long-term treatment with perindopril significantly ameliorated the dobutamine-induced myocardial ischemia, as evaluated by time to the onset of symptoms, magnitude of electrocardiographic ST-segment changes, and left ventricular wall motion score (all P<0.05). The treatment significantly decreased serum ACE activities (P<0.01) and increased plasma bradykinin concentrations (P<0.05). The extent of reduction of left ventricular wall motion score by perindopril was closely correlated with that of inhibition of serum ACE activities (P<0.01) and with that of increase in plasma bradykinin concentrations (P<0.05). By contrast, no such beneficial changes were noted in the control group. These results provide the first evidence that long-term treatment with perindopril exerts anti-ischemic effects on the myocardial ischemia induced by increased myocardial oxygen demand in patients with CAD.
- 社団法人 日本薬理学会の論文
- 2002-01-01
著者
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Shimokawa Hiroaki
Department of Cardiology, Tohoku University School of Medicine
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Tsutsui Masato
Department Of Pharmacology School Of Medicine University Of Occupational And Environmental Health
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Nakashima Yasuhide
Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme
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Yanagihara Nobuyuki
Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health
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Tasaki Hiromi
Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme
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Morishita Tsuyoshi
Second Department of Internal Medicine, University of Occupational and Environmental Health
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Suda Osamu
Second Department of Internal Medicine, University of Occupational and Environmental Health, School
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Horiuchi Masataka
Second Department of Internal Medicine, University of Occupational and Environmental Health
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Morishita Tsuyoshi
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
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Yanagihara Nobuyuki
Department Of Phamacology University Of Occupational And Environmental Health
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Shimokawa Hiroaki
Department Of Cardiology Tohoku University School Of Medicine
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Tasaki Hiromi
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
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Tsuda Yuki
Department Of Cardiology Kitakyushu Municipal Yahata Hospital
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Suda Osamu
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
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Tasaki Hiromi
The 2nd Department Of Internal Medicine University Of Occupational And Environmental Health Japan Sc
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Tsutsui Masato
Department Of Dermatology Asahikawa Medical College
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Kobayashi Kengo
Second Department of Internal Medicine,University of Occupational and Environmental Health,School of
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Kobayashi Kengo
Department Of Internal Medicine Asahi Rosai Hospital
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Nakashima Yasuhide
Second Depadment Of Internal Medicine University Of Occupational And Environmental Health
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Horiuchi Masataka
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
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Okuda Haruhito
Second Department of Internal Medicine, University of Occupational and Environmental Health
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Tsuda Yuki
Second Department of Internal Medicine, University of Occupational and Environmental Health
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Okuda Haruhito
Second Department Of Internal Medicine University Of Occupational And Environmental Health
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Shimokawa Hiroaki
Department Of Cardiovascular Medicine Kyusyu University Graduate School Of Medicine
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Shimokawa Hiroaki
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Science
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Shimokawa Hiroaki
The Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Science
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Matsumoto Tetsuro
Japanese Society Of Chemotherapy (jsc)
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Muratani Tetsuro
Department Of Urology University Of Occupational And Environmental Health
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TSUTSUI Masato
Department of Cardiology, Iizuka Hospital
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