Long-Term Treatment With Imidapril but Not With Nifedipine Enhances Plasma NOx Concentration in Patients With Essential Hypertension
スポンサーリンク
概要
- 論文の詳細を見る
We investigated whether long-term treatment with the angiotensin-converting enzyme (ACE) inhibitor imidapril or the calcium channel antagonist nifedipine increases systemic nitric oxide (NO) production in patients with essential hypertension. Twenty-nine patients with essential hypertension were randomly divided into two groups, and they were treated with either imidapril or nifedipine once daily p.o. for 4 weeks. Long-term treatment with imidapril significantly decreased blood pressure and increased plasma NOx concentration. Long-term treatment with nifedipine also caused a comparable extent of significant decrease in blood pressure, but failed to alter plasma NOx levels. The imidapril treatment significantly inhibited serum ACE activity and increased plasma bradykinin concentration. Furthermore, the extent of inhibition of serum ACE activity and the extent of increase in plasma bradykinin concentration in response to the imidapril treatment were both significantly correlated with the extent of increase in plasma NOx concentration. In contrast, no such changes were noted after the nifedipine treatment. These results provide the first evidence that long-term treatment with imidapril enhances plasma NOx concentration in patients with essential hypertension. This effect does not seem to be due to the decrease in blood pressure. The increase in bradykinin concentration may be involved in the enhancing effect of the ACE inhibitor on NOx production in vivo.
- 社団法人 日本薬理学会の論文
- 2006-06-20
著者
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Tsutsui Masato
Department Of Pharmacology School Of Medicine University Of Occupational And Environmental Health
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Nakashima Yasuhide
Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme
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Yanagihara Nobuyuki
Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health
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Tasaki Hiromi
Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme
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Nakata Sei
Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme
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Okazaki Masahiro
Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme
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Morishita Tsuyoshi
Second Department of Internal Medicine, University of Occupational and Environmental Health
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Kouzuma Ryouji
Second Department of Internal Medicine, University of Occupational and Environmental Health, School
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Suda Osamu
Second Department of Internal Medicine, University of Occupational and Environmental Health, School
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Horiuchi Masataka
Second Department of Internal Medicine, University of Occupational and Environmental Health
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Okazaki Masahiro
Department Of Cardiology And Nephrology University Of Occupational & Environmental Health
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Morishita Tsuyoshi
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
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Yanagihara Nobuyuki
Department Of Phamacology University Of Occupational And Environmental Health
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Tsutsumi Masato
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
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Tasaki Hiromi
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
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Suda Osamu
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
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Nakata Sei
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
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Tasaki Hiromi
The 2nd Department Of Internal Medicine University Of Occupational And Environmental Health Japan Sc
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Kouzuma Ryouji
The Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environ
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Miura Tetsuya
Division Of Urology Kobe University Graduate School Of Medicine
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Tsutsui Masato
Department Of Dermatology Asahikawa Medical College
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SUMIYAMA FUJINISHI
Department of Cardiology, Moji Rousai Hospital
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MIZUKI Tsunetaka
Department of Cardiology, Moji Rousai Hospital
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Nakashima Yasuhide
Second Depadment Of Internal Medicine University Of Occupational And Environmental Health
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Horiuchi Masataka
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
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Mizuki Tsunetaka
Department Of Cardiology Moji Rousai Hospital
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Sumiyama Fujinishi
Department Of Cardiology Moji Rousai Hospital
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Nakashima Yasuhide
Department Of Pharmacology School Of Medicine University Of Occupational And Environmental Health
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Tsutsui Masato
Department Of Pharmacology University Of Occupational And Environmental Health
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Okazaki Masahiro
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Matsumoto Tetsuro
Japanese Society Of Chemotherapy (jsc)
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Muratani Tetsuro
Department Of Urology University Of Occupational And Environmental Health
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TSUTSUI Masato
Department of Cardiology, Iizuka Hospital
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