Hyperhomocysteinemia is Associated With Human Coronary Atherosclerosis Through the Reduction of the Ratio of Endothelium-Bound to Basal Extracellular Superoxide Dismutase

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概要

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• Background Homocysteine is involved in coronary atherosclerosis through oxidative stress, so the present study investigated the association between plasma concentrations of homocysteine and extracellular superoxide dismutase (EC-SOD) in coronary artery disease (CAD). Methods and Results The study group comprised 154 consecutive male patients with suspected CAD who had undergone angiography. Plasma concentrations of homocysteine and EC-SOD, which was determined before (basal) and after heparin therapy, were measured and the difference was designated as endothelium-bound EC-SOD. The EC-SOD ratio (endothelium-bound/basal EC-SOD) was also evaluated as an index of binding capacity. The plasma homocysteine concentration in the stenosis (+) group (n=97, 12.0±4.6μmol/L) was significantly higher than that of the stenosis (-) group (n=57, 10.2±3.0μmol/L, p=0.004). Plasma homocysteine correlated positively with the basal EC-SOD (r=0.377, p<0.001) and negatively with the EC-SOD ratio (r=-0.199, p=0.014). When the group was subdivided according to either homocysteine or the EC-SOD ratio, there were 2 groups with high homocysteine concentration and of these atherosclerosis was reduced in the group with a high EC-SOD ratio. Conclusions In CAD patients, homocysteine is involved in the significant release of EC-SOD from the endothelium. Furthermore, the higher EC-SOD binding capacity, even at high concentrations of homocysteine, suggested that homocysteine-induced atherosclerosis was suppressed. (Circ J 2004 ; 68 : 822-828)

• 社団法人日本循環器学会の論文
• 2004-08-20

著者

• Tsutsui Masato

  Department Of Pharmacology School Of Medicine University Of Occupational And Environmental Health

• Nakashima Yasuhide

  Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme

• ADACHI Tetsuo

  岐阜薬科大学薬剤学教室

• Adachi T

  Laboratory Of Clinical Pharmaceutics Gifu Pharmaceutical University

• ADACHI Tetsuo

  Laboratory of clinical Pharmaceutics, Gifu Pharmaceutical University

• Adachi Tetsuo

  Laboratory Of Clinical Pharmaceutics Gifu Pharmaceutical University

• Tasaki Hiromi

  Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme

• Yamashita Kazuhito

  Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme

• Okazaki Masahiro

  Second Department of Internal Medicine, School of Medicine, University of Occupational and Environme

• Ozumi Kiyoshi

  Second Department of Internal Medicine, University of Occupational and Environmental Health

• Morishita Tsuyoshi

  Second Department of Internal Medicine, University of Occupational and Environmental Health

• Nihei Shun-ichi

  Second Department of Internal Medicine, University Of Occupational and Environmental Health, School

• Ozumi Kiyoshi

  The Second Department of Internal Medicine, University of Occupational and Environmental Health

• Okazaki Masahiro

  Department Of Cardiology And Nephrology University Of Occupational & Environmental Health

• Morishita Tsuyoshi

  Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment

• Tasaki Hiromi

  Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment

• Tasaki Hiromi

  The 2nd Department Of Internal Medicine University Of Occupational And Environmental Health Japan Sc

• Ozumi Kiyoshi

  The Second Department Of Internal Medicine University Of Occupational And Environmental Health

• Tsutsui Masato

  Department Of Dermatology Asahikawa Medical College

• Nihei Shun-ichi

  Second Department Of Internal Medicine University Of Occupational And Environmental Health

• Nakashima Yasuhide

  Second Depadment Of Internal Medicine University Of Occupational And Environmental Health

• Yamamoto Kiyoko

  The Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environ

• Okazaki Masahiro

  Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of

• Matsumoto Tetsuro

  Japanese Society Of Chemotherapy (jsc)

• Muratani Tetsuro

  Department Of Urology University Of Occupational And Environmental Health

• Yamashita Kazuhito

  Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of

• Yamashita Kazuhiko

  Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of

• Yamashita Kazuhito

  産業医科大学 第二内科

• TSUTSUI Masato

  Department of Cardiology, Iizuka Hospital

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