Variable Glyceryl Dinitrate Formation as a Function of Glutathione S-Transferase

スポンサーリンク

概要

• 論文の詳細を見る

• Nitroglycerin (GTN) has been used as the drug of choice in the treatment of angina pectoris. It has been shown that some glutathione S-transferases (GSTs) catalyze the metabolic conversion from GTN to glyceryl dinitrates (GDNs). In this study, we examined the substrate specificity of GSTs for GTN. Alpha and mu GSTs were isolated from porcine liver and intestinal mucosa by means of CM-cellulose and glutathione-affinity column chromatography. Mu GSTs degraded GTN time-dependently and formed 1,3-GDN in preference to 1,2-GDN at a ratio (1,2-GDN/1,3-GDN) of 0.61,whereas alpha GSTs formed twice as much 1,2-GDN as 1,3-GDN. These results showed that two GST families participate in the metabolic conversion of GTN at different hydrolyzing portions of the nitrogroups.

• 社団法人日本薬学会の論文
• 1996-08-15

著者

• 平野 和行

  岐阜薬科大学 薬剤学

• TATEMATSU Masae

  Laboratory of Pathology, Aichi Cancer Center Research Institute

• HIRANO Kazuyuki

  Department ofPharmaceutics, Glfu Pharmaceutical University

• 藤井 澄三

  金沢大学薬学部

• 平野 和行

  岐阜薬科大学薬剤学研究室

• USAMI Yoshiko

  岐阜薬科大学薬剤学教室

• ADACHI Tetsuo

  岐阜薬科大学薬剤学教室

• 平野 和行

  岐阜薬科大学 薬剤学教室

• Adachi T

  Laboratory Of Clinical Pharmaceutics Gifu Pharmaceutical University

• Adachi Tetsuo

  Department Of Pharmaceutics Gifu Pharmaceutical University

• Adachi Tetsuo

  Department Of Clinical Pharmaceutics Gifu Pharmaceutical University

• Usami Y

  Nagoya National Hospital (tokai Area Central Hospital For Aids Treatment And Res.) Aichi Jpn

• USAMI Yoshiko

  Department of Pharmaceutics, Gifu Pharmaceutical University

• FUJII Tomokazu

  Department of Pharmaceutics, Gifu Pharmaceutical University

• Adachi Tetsuo

  Laboratory Of Clinical Pharmaceutics Gifu Pharmaceutical University

• Hirano Kazuyuki

  Radioisotope Laboratory And Department Of Pharmaceutics Gifu Pharmaceutical University

• Tatematsu Masae

  Laboratory Of Pathology Aichi Cancer Center Research Institute

• Hirano Kazuyuki

  Department Of Material Chemistry Graduate School Of Engineering Kyoto University

• Hirano Kazuyuki

  Department Of Pharmaceutcs Gifu Pharmaceutical University

• 藤井 澄三

  Shinshu Univ. Nagano Jpn

• Kizu Hiroto

  Department Of Radiology Kanazawa University Hospital

• HIRANO Kazuyuki

  Department of Clinical Chemistry School of Health Sciences, Fujita Health University

• Tatematsu Masae

  Laboratory of Oncological Pathology, Aichi Cancer Center Research Institute

関連論文

• PP-215 前立腺の腺構造構築における前立腺特異抗原PSAの役割(第95回日本泌尿器科学会総会)
• ホルモン依存性LNCaP細胞のホルモン不応性獲得による生化学的変化(第93回日本泌尿器科学会総会)
• ラット肝臓中のチオエステル水解酵素の精製と性質について
• 13-6-48 HPLC による医薬品分析における移動相の簡便な設定法の検討
• ヌクレオソーム単位でのDNA断片化を伴わない細胞死の解析
• 哺乳類初期胚発生に及ぼす環境因子の解析(妊娠の成立機構 : 胚発生から着床まで)
• Appearance of Osteonectin-expressing Fibroblastic Cells in Early Rat Stomach Carcinogenesis and Stomach Tumors Induced with N-Methyl-N'-nitro-N-nitrosoguanidine
• The Effects of Allyl Alcohol-induced Cell Proliferation for Detection of Initiation Activities of Chemicals in Rat Liver
• The Effects of D-galactosamine- or Carbon Tetrachloride-Induced Regeneration on Induction of Rat Liver Cell Foci in a Model for Detection of Initiation Activities of Chemicals
• More Frequent β-Catenin Gene Mutations in Adenomas than in Aberrant Crypt Foci or Adenocarcinomas in the Large Intestines of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated Rats
• Mouse Strain Susceptibility to Diethylnitrosamine Induced Hepatocarcinogenesis Is Cell Autonomous Whereas Sex-susceptibility Is Due to the Micro-environment:Analysis with C3H【tautomer】BALB/c Sexually Chimeric Mice
• New animal model of glandular stomach carcinogenesis in Mongolian gerbils infected with Helicobacter pylori and treated with a chemical carcinogen
• Development and Distribution of 2-Amino- 1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced Aberrant Crypt Foci in the Rat Large Intestine
• N-Methyl-N-nitrosourea Concentration-dependent, Rather than Total Intake-dependent, Induction of Adenocarcinomas in the Glandular Stomach of BALB/c Mice
• Increased Expression of Sucrase and Intestinal-type Alkaline Phosphatase in Human Gastric Carcinomas with Progression
• Dose-dependent Promoting Effects of Catechol on Glandular Stomach Carcinogenesis in BALB/c Mice Initiated with N-Methyl-N-nitrosourea
• Sparse Distribution of Hepatocyte Growth Factor-producing Cells inside Hepatocellular Foci in Rats Treated with Hepatocarcinogens
• Gastric Tumorigenicity of 1,2-Dimethylhydrazine on the Background of Gastric Intestinal Metaplasia Induced by X-Irradiation in CD (SD) Rats
• Appearance of Osteonectin-expressing Fibroblastic Cells in Early Rat Stomach Carcinogenesis and Stomach Tumors Induced with N-Methyl-N'-nitro-N-nitrosoguanidine
• Appearance of Osteonectin-expressing Fibroblastic Cells in Early Rat Stomach Carcinogenesis and Stomach Tumors Induced with N-Methyl-N'-nitro-N-nitrosoguanidine
• Rare Occurrence of ras and p53 Gene Mutations in Mouse Stomach Tumors Induced by N-Methyl-N-nitrosourea
• Appearance of Osteonectin-expressing Fibroblastic Cells in Early Rat Stomach Carcinogenesis and Stomach Tumors Induced with N-Methyl-N'-nitro-N-nitrosoguanidine
• 1年生「薬を使う薬学」PBLテュートリアルの実施とプロダクト発表に対する評価の分析
• ヒト泌尿器癌組織におけるアミノペプチダーゼ Nの発現と生理活性
• 前立腺癌における膜結合型アミノペプチダーゼ N (CD13) の発現 : 第86回日本泌尿器科学会総会
• インターフェロン-γおよびリポ多糖による併用刺激処理したヒト水晶体上皮細胞株SRA 01/04における過剰産生一酸化窒素の細胞膜Ca^-ATPase遺伝子発現に対する影響
• 遺伝性白内障ICR/fラットの水晶体混濁におけるインターロイキン18およびDNA分解酵素の関与
• Gastric and intestinal mixed and solely intestinal types of intestinal metaplasia in the human stomach
• Dose-dependent Induction of Both Pepsinogen-altered Pyloric Glands and Adenocarcinomas in the Glandular Stomach of C3H Mice Treated with N-Methyl-N-nitrosourea
• Growth Characteristics in the Initial Stage of Micrometastasis Formation by Bacterial LacZ Gene-tagged Rat Prostatic Adenocarcinoma Cells
• Development of Aberrant Crypt Foci Involves a Fission Mechanism as Revealed by Isolation of Aberrant Crypts
• Cellular differentiation and development of pyloric mucosal metaplasia in the human gall-bladder
• 20-P3-510 1回生「薬を使う薬学」PBLテュートリアルの実施とプロダクト発表に対する評価の分析(薬学教育(モデル・コアカリキュラム),来るべき時代への道を拓く)
• 肝臓由来の薬物水解酵素の精製と諸性質の検討
• マウス白血病細胞P388D1由来血管内皮細胞増殖抑制因子
• Expression of heterodimeric (placental-intestinal) hybrid alkaline phosphatase in KB cells.
• 医薬品と食品の相互作用
• 岐阜薬科大学附属薬局の来局者におけるサプリメント利用の実態調査
• 保険薬局来局患者におけるインスリン製剤の使用状況調査 : 効率的な患者指導にむけての調査
• P-166 保険薬局来局患者におけるインスリン製剤の使用状況調査 : 効率的な患者指導にむけての調査(6.服薬指導(入院・外来)4,医療薬学の未来へ翔(はばた)く-薬剤師の薬剤業務・教育・研究への能動的関わり-)
• α-chlorohydrin 暴露したラット精巣上体精子の運動性および先体反応の評価
• 岐阜薬科大学附属薬局における「お薬手帳」の利用状況
• 岐阜薬科大学附属薬局で行った疑義照会内容の分析
• P-311 当薬局が行った疑義照会内容の分析
• 保険薬局実務実習に対する本学学生の意識調査
• 病院実務研修に対する本学学生の意識調査
• Separation and Identification of Urinary Proteins Following Digital Rectal Examination in Patients with Benign Prostatic Hypertrophy
• The Heparin-Binding Site of Human Xanthine Oxidase
• Purification and Characterization of Hamster Hepatic Microsomal N, O-Acetyltransferase
• Enzyme Immunoassay for the Drug of Anti-ulcer Using Avidin-Biotin System
• Establishment and Characterization of Two Cell Lines from N-Methyl-N-nitrosourea-induced Mouse Glandular Stomach Carcinomas
• Activation of Caspase-3, Proteolytic Cleavage of DFF and No Oligonucleosomal DNA Fragmentation in Apoptotic Molt-4 Cells
• Zinc Induces Mixed Types of Cell Death, Necrosis, and Apoptosis, in Molt-4 Cells.
• Zinc Induces Mixed Types of Cell Death, Necrosis, and Apoptosis, in Molt-4 Cells^1
• Decreased Thymosinβ_4 in Apoptosis Induced by a Variety of Antitumor Drugs.
• Induction of Necrosis by Zinc in Prostate Carcinoma Cells and Identification of Proteins Increased in Association with This Induction.
• P2-331 保険薬局における外来がん化学療法患者のQOL向上のための副作用対策支援(一般演題 ポスター発表,癌薬物療法(副作用対策),臨床から学び臨床へと還元する医療薬学)
• ELISA for human tissue-unspecific (liver/bone/kidney) alkaline phosphatase.
• Immunolocalization of Anti-placental Alkaline Phosphatse Monoclonal Antibody in Mice with Testicula Tumors and Lymph Node Metastasis.
• Separation and Identification of Urinary Proteins Following Digital Rectal Examination in Patients with Benign Prostatic Hypertrophy.
• Factors Contributing to Imaging of Xenografts Using Anti-placental Alkaline Phosphatase Monoclonal Antibody.
• A potential use of a monoclonal antibody to placental alkaline phophatase (PLAP) to detect lymph node metatases of seminoma
• Significance of placental alkaline phosphatase (PLAP) in the monitoring of patients with seminoma.
• Serum and tissue levels of manganese superoxide dismutase in testicular germ tumors.
• Immunopathology of alkaline phosphatase isozymes in seminoma.
• Modulation of Reactive Oxygen Species in Endothelial Cells by Peroxynitrite-Treated Lipoproteins
• Aminopeptidase N Regulated by Zinc in Human Prostate Participates in Tumor Cell Invasion.
• Decreases of Metallothionein and Aminopeptidase N in Rental Cancer Tissues.
• Decreases of Metallothionein and Aminopeptidase N in Renal Cancer Tissues
• Hydrolytic Profile for Ester- or Amide-linkage by Carboxylesterases pI 5.3 and 4.5 from Human Liver.
• Hydrolytic Profile for Ester- or Amide-linkage by Carboxylesterases pI 5.3 and 4.5 from Human Liver
• Inhibition of purified human sucrase and isomaltase by ethanolamine derivatives.
• Variable glyceryl dinitrate formation as a function of glutathione S-transferase.
• Variable Glyceryl Dinitrate Formation as a Function of Glutathione S-Transferase
• Inhibition of Purified Human Sucrase and Isomaltase by Ethanolamine Derivatives
• HUMAN AND RAT LIVER-CYTOSOLIC COMPONENTS INVOLVED IN MUTAGENIC ACTIVATION OF AMINO ACID PYROLYSATES
• 合成ステロイド剤ジエノゲストの作用機序に関する研究
• The heparin-binding site of human xanthine oxidase.
• Establishment and Characterization of Three Androgen-independent, Metastatic Carcinoma Cell Lines from 3,2'-Dimethyl-4-aminobiphenyl-induced Prostatic Tumors in F344 Rats
• Inhibition of Aminopeptidase N (AP-N) and Urokinase-Type Plasminogen Activator (uPA) by Zinc Suppresses the Invasion Activity in Human Urological Cancer Cells.
• Extract from Serenoa repens Suppresses the Invasion Activity of Human Urological Cancer Cells by Inhibiting Urokinase-Type Plasminogen Activator.
• Detection of Carcinoembryonic Antigen-expressing Free Tumor Cells in Peritoneal Washes from Patients with Gastric Carcinoma by Polymerase Chain Reaction
• Isolation of Differentiated Squamous and Undifferentiated Spindle Carcinoma Cell Lines with Differing Metastatic Potential from a 4-Nitroquinoline N-Oxide-induced Tongue Carcinoma in a F344 Rat
• Sentinel node navigation surgery using endoscopic minilaparotomy technique for patients with prostate cancer
• Metabolite Profiles of Flutamide in Serum from Patients with Flutamide-Induced Hepatic Dysfunction(Biopharmacy)
• Selection of Mobile Phase in High-Performance Liquid Chromatographic Determination for Medicines.
• Selection of Mobile Phase in High-Performance Liquid Chromatographic Determination for Medicines
• Proliferation, differentiation and morphogenesis of fetal rat glandular stomach transplanted under the kidney capsule of syngeneic hosts
• Histochemical and immunohistochemical study of human gastric carcinoma differentiation with special reference to supplementary role for endosonography in evaluating depth of invasion
• Purification and Characterization of Pranlukast Hydrolase from Rat Liver Microsomes : The Hydrolase is Identical to Carboxylesterase pI 6.2.
• Purification and partial characterization of an indomethacin hydrolyzing enzyme from pig liver.
• Purification and Characterization of Pranlukast Hydrolase from Rat Liver Microsomes : The Hydrolase is Identical to Carboxylesterase pI 6.2
• Induction of Glandular Stomach Cancers in Helicobacter pylori-sensitive Mongolian Gerbils Treated with N-Methyl-N-nitrosourea and N-Methyl-N'-nitro-N-nitrosoguanidine in Drinking Water
• Dendritic Cell Appearance and Differentiation during Early and Late Stages of Rat Stomach Carcinogenesis
• The alkaline phosphatase in human plexus chorioideus.
• Binding of human xanthine oxidase to sulphated glycosaminoglycans on the endothelial-cell surface.
• The Heparin Binding Site of Human Extracellular-Superoxide Dismutase.
• The Site of Nonenzymic Glycation of Human Extracellular-Superoxide Dismutase in vitro.
• Non-enzymic glycation of human extracellular superoxide dismutase.
• 遺伝性白内障ICR/fラットの水晶体混濁におけるインターロイキン18およびDNA分解酵素の関与

もっと見る 閉じる

スポンサーリンク