Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases : Aquaporins in the Brain
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概要
- 論文の詳細を見る
Water homeostasis of the brain is essential for its neuronal activity. Changes in water content in the intra- and extra-cellular space affect ionic concentrations and therefore modify neuronal activity. Aquaporin (AQP) water channels may have a central role in keeping water homeostasis in the brain. Among AQP subtypes cloned in mammalian, only AQP1, AQP4, and AQP9 were identified in the brain. Changes in AQP expression may be correlated with edema formation of the brain. In this review, we describe the physiological function of AQPs and the regulatory mechanism of their expression in the brain.
- 社団法人 日本薬理学会の論文
- 2004-11-20
著者
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KOBAYASHI Hideyuki
Department of Structural Pathology, Institute of Nephrology
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Kobayashi Hideyuki
Department Of Cardiology Tokyo Medical University
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WADA Akihiko
Department of Radiology, Shimane Medical College
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Kobayashi Hideyuki
Department Of Pharmacology Miyazaki Medical College University Of Miyazaki
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Wada Akihiko
Dep. Of Pharmacology Miyazaki Medical Coll. Univ. Of Miyazaki Jpn
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Wada Akihiko
Department Of Hygiene Fujita Health University Of Medicine
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YOKOO Hiroki
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki
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YANAGITA Toshihiko
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki
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Yokoo Hiroki
Department Of Pharmacology Miyazaki Medical College University Of Miyazaki
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Yanagita Toshihiko
Dep. Of Pharmacology Miyazaki Medical Coll. Univ. Of Miyazaki Jpn
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Yanagita Toshihiko
Department Of Pharmacology Miyazaki Medical College University Of Miyazaki
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Kobayashi Hideyuki
Department Of Aeronautical Engineering Kyoto University
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Yokoo Hiroki
Department Of Molecular And Medical Pharmacology Graduate School Of Medicine And Pharmaceutical Scie
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