Ability of Mosapride to Bind to 5-HT_4 Receptor in the Human Stomach
スポンサーリンク
概要
- 論文の詳細を見る
Ability of mosapride, a gastrokinetic agent, to bind to 5-HT4 receptor was examined in the stomach of human and guinea pig by in vitro receptor autoradiography. [125I]SB207710 binding sites were detected in the muscle layer including the myenteric plexus of the stomach from both humans and guinea pigs, although the binding was observed more clearly and densely in the stomach of guinea pigs than humans. Mosapride as well as SB204070 inhibited the binding of [125I]SB207710. Thus, mosapride possesses the ability to bind to 5-HT4 receptors of human stomach and may modulate the motility, as in the case of guinea pig stomach.
- 社団法人 日本薬理学会の論文
- 1999-04-01
著者
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Kanematsu T
Division Of Surgery Department Of Translational Medical Sciences Nagasaki University Graduate School
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Kanematsu Takashi
Surgery II, Nagasaki Univercity School of Medicine
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Kanematsu Takashi
長崎大学 医歯薬総研究外科学
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Kanematsu Takashi
Div. Of Surgery Dep. Of Translational Medical Sciences Nagasaki Univ. Graduate School Of Biomedical
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Enjoji Akihito
Division Of Surgery Department Of Translational Medical Sciences Nagasaki University Graduate School
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TANIYAMA Kohtaro
Pharmacology, Nagasaki University School of Medicine
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Sakurai-yamashita Yasuko
Departments Of Pharmacology Nagasaki University Graduate School Of Biomedical Sciences
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Sakurai‐yamashita Y
Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn
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Sakurai(yamashita) Yasuko
Department Of Pharmacology Nagasaki University Graduate School Of Biomedical Sciences
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Taniyama K
Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn
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SAKURAI-YAMASHITA Yasuko
Pharmacology Departments Nagasaki University School of Medicine
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TAKADA Kohei
Pharmacology Departments Nagasaki University School of Medicine
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TAKEMURA Keiko
Pharmacology Departments Nagasaki University School of Medicine
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YAMASHITA Kimihiro
Section of Pharmacology, Department of En vironmental Conservation, Faculty of Environmental Studies
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ENJOJI Akihito
Surgery II Departments Nagasaki University School of Medicine
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Taniyama Kohtaro
Division Of Pharmacology Department Of Translational Medical Sciences Nagasaki University Graduate S
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Taniyama K
Division Of Pharmacology Department Of Translational Medical Sciences Nagasaki University Graduate S
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Takemura Keiko
Department Of Pharmacology Nagasaki University School Of Medicine
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Yamashita Kimihiro
Section Of Pharmacology Department Of En Vironmental Conservation Faculty Of Environmental Studies N
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