Rapid Loss of Graft Immunogenicity and Transient Hyporesponsiveness to The Donor Antigen After Rat Liver Transplantation
スポンサーリンク
概要
- 論文の詳細を見る
In orthotopic liver transplantation from Lewis (LEW) into Wistar Furth (WF) rats, a transient acute rejection response is usually followed by spontaneous tolerance of the graft. In this study, we investigated the alloimmunostimulatory ability of the graft and recipient spleen after liver transplantation, and studied the kinetic response of the recipient to the donor antigen. Alloimmunogenicity of the liver graft and recipient spleen, and kinetic response of the recipient were investigated in in vivo system. Alloimmunostimulatory ability of the liver graft disappeared by day 3 after transplantation. Alloimmunostimulatory capacity of recipient spleen was maximum 12 hours after grafting and rapidly disappeared thereafter. Challenge with normal LEW lymphocytes into recipient WF rats at 14, 28, 56 days after liver transplantation induced a progressive increase in rejection response. Our results suggest that rapid loss of graft immunogenicity and transient hyporesponsiveness to the donor antigen occur after grafting in our model.
- 長崎大学の論文
著者
-
YAMAGUCHI Junzo
Department of Surgery, National Hospital Organization Saga Hospital
-
Yamaguchi Junzo
Department Of Parasitology And Immunology Okayama University Medical School
-
Yamaguchi Junzo
Second Department Of Surgery Nagasaki University School Of Medicine
-
GU WEILI
Department of Surgery II, Nagasaki University School of Medicine
-
HASHIMOTO TOSHIAKI
Department of Surgery II, Nagasaki University School of Medicine
-
Gu Weili
Second Department of Surgery, Nagasaki University School of Medicine
-
Gu Weili
Second Department Of Surgery Nagasaki University School Of Medicine
-
Kanematsu Takashi
Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica
-
Yamamoto Takao
Department of Surgery II, Nagasaki University School of Medicine
関連論文
- Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation.
- Torsion of the gallbladder in a 3-year-old infant
- Hepatitis C virus kinetics during the first phase of pegylated interferon-alpha-2b with ribavirin therapy in patients with living donor liver transplantation.
- Multicentric occurrence and spread of hepatocellular carcinoma in whole explanted end-stage liver.
- A secure taping technique for a liver hanging maneuver using a surgical probe.
- Re-evaluation of lipiodolized transarterial chemoembolization therapy for intrahepatic recurrence of hepatocellular carcinoma after curative liver resection.
- Compressive stenosis of the inferior vena cava due to localized ascites after living-donor liver transplantation.
- Evolution of living donor liver transplantation over 10 years: experience of a single center.
- Inactivation of porcine endogenous retrovirus by human serum as a function of complement activated through the classical pathway
- A new suppressive agent against interleukin-1β and tumor necrosis factor-α enhances liver regeneration after partial hepatectomy in rats
- An Unusual Perforation of the Colon : Report of Two Cases
- Impaction of a Shrapnel Splinter in the Common Bile Duct After Migrating from the Right Thoracic Cavity : Report of a Case
- Hepatic expression and serum levels of thrombomodulin reflect the extent of liver injury in rats with fulminant hepatic failure and extensive hepatectomy
- Successful Repeated Transcatheter Arterial Embolization (TAE) for Multiple Liver Metastases from Breast Cancer
- A Case of Ductal Dysplasia of the Pancreas A Possible Prerequisite for Pancreatic Cancer
- I1-5 Role of intrasplenic hepatocyte transplantation in preventing postoperative liver failure in cirrhotic rats.
- Presence of GABA_B Receptors Forming Heterodimers With GABA_ and GABA_ Subunits in Human Lower Esophageal Sphincter
- Intraoperative pancreatography and gastric-wall-covering method for the prevention of pancreatic leakage after enucleation of insulinoma in the pancreas
- Common Fragile Genes and Digestive Tract Cancers
- Hepatolithiasis and intrahepatic cholangiocarcinoma : carcinogenesis based on molecular mechanisms
- Parapapillary choledochoduodenal fistula associated with cholangiocarcinoma
- Genetic Alterations in Gallbladder Carcinoma
- Role of Hypermethylation on Carcinogenesis in the Pancreas
- Utilization of Jejunal Segment has Benefit for Reconstruction of the Extrahepatic Bile Duct in the Canine
- A New, Secure Drainage Method from the Cystic Duct After Choledocholithotomy Using the Cystic Tube and the Cystic Clip : An Experimental Study
- Ruptured Aneurysm of the Visceral Artery : Report of Two Cases
- CD4 T-Cell Regulation of Cytotoxic T Cells During the Induction Phase of Liver-Induced Spontaneous Tolerance in Rats
- Rapid Loss of Graft Immunogenicity and Transient Hyporesponsiveness to The Donor Antigen After Rat Liver Transplantation
- Vacuum-assisted biopsy and steroid therapy for granulomatous lobular mastitis: report of three cases.
- Hepatic resections for bilobar liver metastases from colorectal cancer
- Acceleration by KW-5092 of Intestinal Motility Associated With Acetylcholine Release In Vivo
- Surgical Treatment of a Case of Early Infantile Epileptic Encephalopathy with Suppression-Bursts Associated with Focal Cortical Dysplasia
- Tremor and seizures associated with chronic manganese intoxication
- MRI facilitated a diagnosis of endometriosis of the rectum
- μ-Opioid Receptor Forms a Functional Heterodimer With Cannabinoid CB_1 Receptor : Electrophysiological and FRET Assay Analysis
- Gastric Necrosis After an Infarction of the Spleen : Report of a Case
- Attenuated Familial Adenomatous Polyposis Associated with Advanced Rectal Cancer in a 16-Year-Old Boy : Report of a Case
- Small-Cell Carcinoma of the Gallbladder : Report of a Case
- Intrahepatic Cholangiocarcinoma with Extensive Sarcomatous Change: Report of a Case
- Administration of secretin for autism alters dopamine metabolism in the central nervous system
- Protective effects of a hibernation-inducer on hepatocyte injury induced by hypothermic preservation
- Biliary complications in recipients of living-donor liver transplantation
- Patients with West syndrome whose ictal SPECT showed focal cortical hyperperfusion
- Successful Management of Intractable Epilepsy with Lidocaine Tapes and Continuous Subcutaneous Lidocaine Infusion
- Characterization of GABA_B Receptors Involved in Inhibition of Motility Associated With Acetylcholine Release in the Dog Small Intestine : Possible Existence of a Heterodimer of GABA_ and GABA_ Subunits
- Characterization of GABA_B Receptor in the Human Colon
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- In Vivo Assessment of Acceleration of Motor Activity Associated With Acetylcholine Release via 5-Hydroxytryptamine_4 Receptor in Dog Intestine
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- A second primary esophageal cancer developing 7 years after chemoradiotherapy for advanced esophageal cancer
- Functions of peripheral 5-hydroxytryptamine receptors, especially 5-hydroxytryptamine-4 receptor, in gastrointestinal motility
- Tetanus After a Resection for a Gangrenous Perforated Small Intestine: Report of a Case
- Transient seizure disappearance due to bilateral striatal necrosis in a patient with intractable epilepsy
- Polymer Properties on Resins composed of UDMA and Methacrylates with the Carboxyl Group
- Successful Left Adrenalectomy for Metastatic Hepatocellular Carcinoma Using Hand-Assisted Laparoscopic Surgery : Report of a Case
- Clinical Significance of Telomerase Activity and Telomere Length in Various Liver Diseases
- A Free Jejunal Reconstruction Following the Failure of an Initial Esophageal Reconstruction with Colic Pedicle - Report of a Case
- Management and Long-term Follow-up of a Case in a Child with Traumatically Avulsed Maxillary Incisor Accompanied by Mesiodens(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Characteristic evoked potentials in childhood-onset dentatorubral-pallidoluysian atrophy
- Proton magnetic resonance spectroscopy on childhood-onset dentatorubral-pallidoluysian atrophy (DRPLA)
- The Serum Level of Carcinoembryonic Antigen in Drainage Venous Blood Is Not a Sensitive Predictor of Metachronous Hepatic Metastasis for Patients with Colorectal Cancer
- Systematic laparoscopic left lateral segmentectomy of the liver for hepatocellular carcinoma
- Detection of Carcinoembryonic Antigen mRNA in the Mesenteric Vein of Patients with Resectable Colorectal Cancer
- Effect of grape seed proanthocyanidins extract on alteration of mechanical properties of metaphysis tibia bone in rats fed a low-calcium diet
- Polysomnographic studies of Lesch-Nyhan syndrome
- Efficacy and limitation of bone marrow transplantation in the treatment of acute and subacute liver failure in rats
- The outcomes of methicillin-resistant Staphylococcus aureus infection after living donor liver transplantation in a Japanese center
- Living-donor liver transplantation from second generation children for atomic bomb survivors
- Patient allocation based on preoperative assessment of pancreatic fibrosis to secure pancreatic anastomosis performed by trainee surgeons : a prospective study
- Hand-assisted laparoscopic total pancreatectomy for a main duct intraductal papillary mucinous neoplasm of the pancreas.
- Utility of Preoperative Dynamic Magnetic Resonance Imaging of the Pancreas in Diagnosing Tumor-Forming Pancreatitis that Mimics Pancreatic Cancer : Report of a Case
- Intraductal papillary mucinous neoplasm of the pancreas with a bifid pancreatic duct.
- A Combination Procedure with Thrombolytic Therapy and Balloon Dilatation for Portal Vein Thrombus Enables the Successful Performance of Antiviral Therapy After a Living-Donor Liver Transplantation : Report of a Case
- Alanyl-glutamine provides beneficial nutritional support after orthotopic transplantation of the liver in pigs
- Prediction and management of a low-lying costal arch which restricts the operative working space during laparoscopic cholecystectomy
- Living Donor Liver Transplantation with Extensive Caval Thrombectomy for Acute-on-Chronic Budd-Chiari Syndrome
- Significance of serum β-D-glucan levels in recipients of living donor liver transplantation
- Technical refinements of bile duct division in living donor liver surgery
- Parenchymal leiomyoma of the breast : a case report with special reference to magnetic resonance imaging findings and an update review of literature
- Liver transplantation for patients with human immunodeficiency virus and hepatitis C virus coinfection with special reference to hemophiliac recipients in Japan.
- Hemophagocytic Syndrome After Liver Transplantation : Report of Two Cases
- Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas : report of a case
- Prevention of gastric stasis by omentum patching after living donor left hepatectomy
- Use of stepwise versus straightforward clamping of biliary drainage tubes after living-donor liver transplantation : a prospective, randomized trial