The inactivation of (Met5)-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens.
スポンサーリンク
概要
- 論文の詳細を見る
The enkephalin-hydrolyzing peptidases in mouse vas deferens were studied and compared with those in guinea pig ileum which had been characterized in the previous study. The present results showed that three distinct peptidases, bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A, and thiorphan-sensitive endopeptidase-24.11, played a critical role in the inactivation of enkephalin in mouse vas deferens, being consistent with the previous results obtained with guinea pig ileum. However, the data in both previous and present studies showed that the activity of the bestatin-sensitive aminopeptidase relative to that of either the captopril-sensitive peptidyl dipeptidase A or the thiorphan-sensitive endopeptidase-24.11 in guinea pig ileum was higher than that in mouse vas deferens, while the activity of either peptidyl dipeptidase A or endopeptidase-24.11 relative to that of aminopeptidase in mouse vas deferens was higher than that in guinea-pig ileum. In contrast to these three enzymes, both L-tyrosyl-L-tyrosine-sensitive dipeptidyl aminopeptidase and D-phenylalanine-sensitive carboxypeptidase were suggested not to be involved significantly in the inactivation of enkephalin in mouse vas deferens as well as guinea pig ileum.
著者
-
Aoki Kazuko
Departamento Sistemas Biologicos Universidad Autonoma Metropolitana-xochimilco
-
OKA Tetsuo
Department of Clinical Pharmacology, School of Medicine, Tokai University
-
KAJIWARA Midori
Department of Pharmacology, School of Medicine, Tokai University
関連論文
- Stimulus effects of the medial pontine reticular formation and the mesencephalic locomotor region upon medullary reticulospinal neurons in acute decerebrate cats
- Great Increase in Antinociceptive Potency of [Leu^5]Enkephalin After Peptidase Inhibition
- The Enhancing Effects of Peptidase Inhibitors on the Antinociceptive Action of [Met^5]Enkephalin-Arg^6-Phe^7 in Rats
- Time Course of Changes in μ-Opioid Receptor mRNA Levels in the Periaqueductal Gray of Rat Brain by a Single or Repeated Injections of Antisense Oligodeoxynucleotides
- Long-Term Treatment With Morphine Increases the D-Serine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase
- Effects of Peptidase Inhibitors on the Enkephalin-Induced Anti-nociception in Rats
- Effects of Fusaric (5-butylpicolinic) Acid on the Monosynaptic Reflex Neural Activity of Cat Spinal Cord
- Effects of Peripheral Monoamines on the Monosynaptic Reflex Neuronal Activity of Acute Spinal Cats
- Effects of Muscarinic Cholinergic Antagonists or p-Chlorophenylalanine on the Morphine-Induced Increase in Striatal Homovanillic Acid Concentration of Rats
- Effects of 5, 7-Dihydroxytryptamine on Brain Monoamine Contents and on Morphine-Induced Hypothermia in Rats
- New μ-Opioid Receptor Agonists with Phenoxyacetic Acid Moiety
- New μ-Opioid Receptor Agonists with Piperazine Moiety
- The Effect of Naloxone on C-Fiber Reflex in Cats
- EFFECTS OF NARCOTIC ANALGESICS ON SEROTONIN METABOLISM IN BRAIN OF RATS AND MICE
- The Effects of Morphine, Naloxone and Capsaicin on C-fiber Reflex and Heat Evoked Discharge in Acute Spinal Cats
- EFFECT OF HUMORAL MODULATORS ON MORPHINEINDUCED INCREASE IN LOCOMOTOR ACTIVITY OF MICE
- The Effect of Capsaicin on C-fiber Reflex and Heat Evoked Discharge in the Acute Spinal Cat
- The Effects of Droperidol and Diazepam on the Neural Excitation of Ketamine Hydrochloride
- Two New Opioid Delta-Receptor Ligands: A Highly Selective Agonist and a Potent Selective Antagonist in in Vitro Isolated Preparations
- Long-Term Treatment With Morphine Increases the D-Serine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase
- Characteristics of Opioid Receptors in Guinea-Pig Cerebellum and Human Placenta
- MEASUREMENT OF FLUORESCENCE SPECTRA AS A NEW TECHNIQUE FOR STUDY OF SEDIMENTARY ZIRCONS
- Microspectrofluorometry of Colorless Zircons
- Studies on the Fluorescence of Zircons(1)Types of Fluorescence Spectrum
- Relation of Diltiazem Binding Sites to Opioid Receptor Subtypes in the Guinea-pig Brain
- Human Serum Dopamine-β-hydroxylase Activity as a Marker of Sympathoadrenal Activity
- The Antispasmodic Activity of Buddleja scordioides and Buddleja perfoliata on Isolated Intestinal Preparations(Pharmacognosy)
- Source of Rounded Zircons from Permian SedimentsExposed in the River Tainai Area, Niigata Prefecture, Japan
- Inactivation of dynorphin-(1-8) in isolated preparations by three peptidases.
- Estimation of relative importance of three enzymes in the inactivation of (Met5)-enkephalin and (Met5)-enkephalin-Arg6 in three isolated preparations by employing the inhibitor specific for each enzyme.
- Agonist and antagonist actions of buprenorphine on three types of opioid receptor in isolated preparations.
- The inactivation of (Met5)-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens.
- The relative potency of enkephalins and .BETA.-endorphin in guinea-pig ileum, mouse vas deferens and rat vas deferens after the administration of peptidase inhibitors.
- The enhancing effects of amastatin, phosphoramidon and captopril on the potency of (Met5)-enkephalin in rat vas deferens.
- Regulation of opioid antagonist and mu, kappa or delta agonist binding by guanine nucleotide and sodium.
- The Enhancing Effects of Peptidase Inhibitors on the Antinociceptive Action of [Met5]Enkephalin-Arg6-Phe7 in Rats
- The role of bestatin-sensitive aminopeptidase, angiotensin converting enzyme and thiorphan-sensitive "enkephalinase" in the potency of enkephalins in the guinea-pig ileum.
- Effects of peptidase inhibitors on the (Met5)-enkephalin hydrolysis in ileal and striatal preparations of guinea-pig: Almost complete protection of degradation by the combination of amastatin, captopril and thiorphan.
- SIMPLE, SENSITIVE AND RAPID METHODS FOR THE DETECTION OF MORPHINE IN URINE
- Fluorescence Spectra of Zircons from italian AlpinePlutonic Rocks