The Effect of Naloxone on C-Fiber Reflex in Cats

概要

論文の詳細を見る
The specific opiate antagonist naloxone rapidly reverses hypotention caused by endotoxin, hypovolemia and spinal transection. The fact that naloxone appears to act at a causative level to improve shock pathophysiology, as well as its extensive clinical use for opiate overdose, makes this drug a particularly clinical use for opiate overdose, makes this drug a particularly attractive potential therapeutic agent for the treatment of shock in humans. The electrophysiological effects of naloxone were studied on c-fiber reflex in spinal and intact cats. The drugs were injected in to the right cephalic vein. Results can be summarized as follows: 1) Naloxone in the intact cat had a more pronounced facilitating effect than in the spinal cat. 2) Naloxone given as a one shot injection was more potentiating than naloxone given as a 5 minute injection. 3) Naloxone antagonized the facilitation of a small dose of ketamine-HCL in the intact cat and also the depression of a large dose ketamine-HCL. 4) Naloxone antagonized capsaicin on c-fiber reflex. This result supports that naloxone has the antagonizable inhibitory effect of substance-P. 5) Naloxone for the first injection had an effective response but additional naloxone did not facilitate the c-fiber reflex.
東海大学の論文