The Effect of Capsaicin on C-fiber Reflex and Heat Evoked Discharge in the Acute Spinal Cat
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概要
- 論文の詳細を見る
The effects of capsaicin were studied electrophysiologically on C-fiber reflex and heat-evoked discharge in adult spinal cats. The results can be summarized as follows: 1) 125μg/Kg of capsaicin, administered intravenously, induced an increase in spontaneous discharge in the L_7 ventral root; 2) 250μg/Kg of capsaicin, administered intravenously, induced an increase in the C-fiber reflex response; 3) 125μg/Kg of capsaicin, administered intravenously, induced an increase in the heat-evoked discharge; but 4) 25μg/Kg of capsaicin, administered through the femoral artery, did not show significant alteration of the heat-evoked discharge. These findings suggest that capsaicin which produced a release of substance-P from primary afferent nerves may principally act on C-fiber and Aδ-fiber. Capsaicin was much more effective on the heat-evoked discharge than on the C-fiber reflex when administered intravenously.
- 東海大学の論文
著者
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MATSUMIYA Teruhiko
Department of Pharmacology, Tokyo Medical University
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OKA Tetsuo
Departmnet of Orthopedics, Asahikawa Medical College
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Oka Tetsuo
Department Of Pharmacology School Of Medicine Tokai University
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Sawa Aiko
Department Of Pharmacology School Of Medicine Tokai University
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Matsumiya Teruhiko
Department Of Pharmacology And Intractable Diseases Research Center Division Of Drug Research And De
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OKA Tetsuo
Department of Clinical Pharmacology, School of Medicine, Tokai University
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Sawa Aiko
Department of Applied Chemistry, Faculty of Engineering, Keio University
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