Changes in Immune Responses to Mite Antigen Sensitized through Barrier-Disrupted Skin with CpG-Oligodeoxynucleotide in Mice(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
CpG-oligodeoxynucleotide (CpG-ODN) plays a critical role in immunity via the augmentation of Th1 and suppression of Th2 responses. We examined here the effect of CpG-ODN on the immune response to mite antigen sensitized through barrier-disrupted skin of human atopic dermatitis (AD) model mouse. Although sensitization with mite antigen induced Th2-dominant immune response, co-administration of CpG-ODN elicited Th1-predominant immune response. In terms of antigen-specific antibody production, the level of IgG2a was increased by CpG-ODN, but not in IgE. These results suggested that administration of CpG-ODN via skin is a simple strategy for patients with diseases like AD, which is characterized by Th2-dominated inflammation.
- 2006-02-01
著者
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ARAMAKI Yukihiko
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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SAKAMOTO Takatoshi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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TSUCHIYA Seishi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Sakamoto T
Second Department Of Surgery Toyama Medical And Pharmaceutical University
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Tsuchiya Seishi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Sakamoto T
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Aramaki Yukihiko
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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INOUE Joe
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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YOTSUMOTO Satoshi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Inoue Joe
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Yotsumoto Satoshi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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