Studies of Nitriles. X. Synthesis and Reactions of 2-Acylamino-3,3-bis-(substituted mercapto) acrylonitriles and Their Derivatives. A New Synthesis of 2-Substituted-5-(substituted mercapto) oxazole-4-carbonitriles and Their Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
The reaction of 2-acylamino-3,3-dichloroacrylonitriles (1) with various mercaptans in the presence of base gives 2-acylamino-3,3-bis (substituted mercapto) acrylonitriles (5) or 2-acylamino-3-chloro-3-(substituted mercapto) acrylonitriles (17), each in good yield, depending upon the amount of mercaptans used. Similar nucleophilic substitutions are possible with the corresponding amides (8,9), N-acylamides (10), esters (7), and acid (11). Treating the 3-mercapto acrylic acid derivatives thus obtained with silver compounds, such as Ag_2O, Ag_2CO_3,and CH_3COOAg, gives an excellent new method for synthesizing 5-(substituted mercapto) oxazoles (4). The scope and limitations of this new cyclization are also described.
- 公益社団法人日本薬学会の論文
- 1976-05-25
著者
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橋本 直人
Central Research Division Takeda Chemical Industries Ltd.
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宮下 修
Central Research Division, Takeda Chemical Industries, Ltd.
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橋本 直人
Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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松村 興一
Central Research Division, Takeda Chemical Industries, Ltd.
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松村 興一
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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島津 浩
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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宮下 修
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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島津 浩
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industires
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宮下 修
Central Research Division Takeda Chemical Industries Ltd.
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松村 興一
Central Research Division Takeda Chemical Industries Ltd.
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