Studies on Fluorinated Pyrimidines. IV. Stereochemistry of 6-Alkoxy-5-fluoro-5,6-dihydrouracils and 5-Alkoxycarbonyl-5-fluoro-6-substituted-5,6-dihydrouracils
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概要
- 論文の詳細を見る
Both cis (6) and trans (7) isomers of 6-alkoxy-5-fluoro-5,6-dihydrouracils were prepared by catalytic hydrogenolysis of t-6-alkoxy-r-5-halogeno-5-fluoro-5,6-dihydrouracils (4 and 5). The structures were estimated by comparing coupling constants (J_<H_6F>) in the proton magnetic resonance (PMR) spectra and confirmed by a single-crystal X-ray analysis of cis-6-ethoxy-5-fluoro-5,6-dihydrouracil (6a). The stereochemistry of 6-alkoxy-5-alkoxycarbonyl-5-fluoro-5,6-dihydrouracils (11-13) was clarified similarly on the basis of the PMR data. The chemical behavior of these compounds in acidic and basic media was examined.
- 公益社団法人日本薬学会の論文
- 1982-07-25
著者
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笠原 俊彦
Central Research Division Takeda Chemical Industries Ltd.
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橋本 直人
Central Research Division Takeda Chemical Industries Ltd.
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高本 正幸
Central Research Division, Takeda Chemical Industries, Ltd.
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宮下 修
Central Research Division, Takeda Chemical Industries, Ltd.
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松村 興一
Central Research Division, Takeda Chemical Industries, Ltd.
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島津 浩
Central Research Division, Takeda Chemical Industries, Ltd.
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島津 浩
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industires
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宮下 修
Central Research Division Takeda Chemical Industries Ltd.
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高本 正幸
Faculty of Pharmaceutical Sciences, Tokyo University
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松村 興一
Central Research Division Takeda Chemical Industries Ltd.
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高本 正幸
Faculty Of Pharmaceutical Sciences Tokyo University
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高本 正幸
Central Research Division Takeda Chemical Industries Ltd.
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