Studies on Fluorinated Pyrimidines. V. Preparation of optically Active (+)-and (-)-t-6-Butoxy-r-5-ethoxycarbonyl-5-fluoro-5,6-dihydrouracils
スポンサーリンク
概要
- 論文の詳細を見る
Both optical isomers of t-6-butoxy-r-5-ethoxycarbonyl-5-fluoro-5,6-dihydrouracil (1,TAC-278), a new candidate for use as a pro-drug of 5-fluorouracil (5-FU), have been prepared via the enantiomeric 6-(+)-and 6-(-)-α-methylbenzylamino derivatives (4).
- 公益社団法人日本薬学会の論文
- 1982-08-25
著者
-
笠原 俊彦
Central Research Division Takeda Chemical Industries Ltd.
-
和田 喜一
Central Research Division, Takeda Chemical Industries, Ltd. Kusunoki-cho, Ikuta-ku, Kobe
-
宮下 修
Central Research Division, Takeda Chemical Industries, Ltd.
-
宮下 修
Central Research Division Takeda Chemical Industries Ltd.
-
和田 喜一
Central Research Division Takeda Chemical Industries Ltd.
関連論文
- Effect of a Minor Component on Thermal Transformation of Crystalline 6-Mercaptopurine
- Synthesis and Enzymatic Activity of Adenosine 3', 5'-Cyclic Phosphate Analogs
- Synthesis and Coronary Vasodilating Activity of 2-Substituted Adenosines
- Structure of 6,3' : 6,5'-Dianhydro-5,5-dibromo-5,6-dihydro-6,6-dihydroxy-1-(β-D-xylofuranosyl) uracil
- 5-Hydroxy-1-(2-hydroxyethyl)-6,7,8-trimetlyl-2-thia-7-azabicyclo〔3,3,0〕octane Hemihydrateの結晶構造解析Thiamineのアルカリ分解物の構造
- X-Ray Analysis of an Aminoglycoside Antibiotic P-2563 (P) Monohydrobromide
- X-Ray Analysis of 9-Propionylmaridomycin III Iodo Adduct
- Struktur und Absolute Konfiguration von Diosbulbin-A, -B und -C. Die Kristallanalyse von 3-Bromo-2-oxo-tetrahydrodiosbulbin-A
- Studies on Fluorinated Pyrimidines. IV. Stereochemistry of 6-Alkoxy-5-fluoro-5,6-dihydrouracils and 5-Alkoxycarbonyl-5-fluoro-6-substituted-5,6-dihydrouracils
- Studies on Fluorinated Pyrimidines. III. Synthesis of 1-Acyl- and 1,3-Diacyl-5-alkoxycarbonyl-5-fluoro-6-substituted-5,6-dihydrouracils
- Studies on Fluorinated Pyrimidines. II. Synthesis and Antitumor Activity of 5-Fluoro-6-substituted-5,6-dihydrouracil-5-carboxylic Acid Derivatives
- Studies on Fluorinated Pyrimidines. I. A New Method of Synthesizing 5-Fluorouracil and Its Derivatives
- Studies of Nitriles. X. Synthesis and Reactions of 2-Acylamino-3,3-bis-(substituted mercapto) acrylonitriles and Their Derivatives. A New Synthesis of 2-Substituted-5-(substituted mercapto) oxazole-4-carbonitriles and Their Derivatives
- Studies of Nitriles. IX. Reactions of 2-Acetylamino-3,3-dichloroacrylic Amide and-N-acylamide with Aliphatic Amines. (2). Syntheses of Some α, α-Diamino Acid Derivatives
- Studies on Fluorinated Pyrimidines. V. Preparation of optically Active (+)-and (-)-t-6-Butoxy-r-5-ethoxycarbonyl-5-fluoro-5,6-dihydrouracils
- Usnic Acid. XVI. Alkaline Degradation of Dihydrousnic Acid
- Polymorphism of Thiamine Hydrochloride. II. Crystal Structure of Thiamine Hydrochloride Hemihydrate and Its Stability
- 6.ビタミンB_1塩酸塩の多形 : Phase IIの結晶構造とPhase I, II相互の安定性(ビタミンB研究委員会 : 第252回会議研究発表要旨)
- Synthesis and Biological Activities of Optical Isomers of 2-(4-Diphenylmethyl-1-piperazinyl)ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (Manidipine) Dihydrochloride
- Crystal and Molecular Structure of Cefmenoxime Hemihydrochloride
- Crystal Structure of (±)-trans-2-Cyclobutylamino-5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthalenol Hydrobromide
- X-Ray Analysis of d-6-Chloro-5-cyclohexylindan-1-carboxylic Acid (d-TAI-284)
- Molecualr Structures of 8-Chloro-6-phenyl-4H-8-triazolo [4,3-a] [1,4] benzodiazepine, 2-Acetoxyamino-4-acetyl-8-chloro-3,4-dihydro-6-phenyl-1,4,5-benzotriazocine and 8-Chloro-4,11-diacetyl-4,11-dihydro-2-methyl-6-phenyloxazolo [4,5-b]-[1,4,5] benzotriazoc
- Semisynthetic β-Lactam Antibiotics. IV. The X-Ray Analysis of Monopotassium α-Sulfophenylacetate Monohydrate. The Configuration of the Acyl Side Chain of α-Sulfobenzylpenicillin
- Syntheses of conformationally Rigid Catecholamine Derivatives
- Fused Pyrimidines. I. A One-step Synthesis of 3-Aminoisothiazolo [3,4-d]-pyrimidines from 6-Aminouracils and Vilsmeier Reagents
- A New Reaction of Nucleotides with Cyanoacetylene
- X-Ray Analysis of L-Ascorbic Acid 2-o-Phosphate
- Studies on the Characteristics of Carbochromen Hydrochloride Crystals. I. Polymorphism and Behavior of Water of Crystallization