X-Ray Analysis of d-6-Chloro-5-cyclohexylindan-1-carboxylic Acid (d-TAI-284)
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概要
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The absolute configuration at C-1 of d-6-chloro-5-cyclohexylindan-1-carboxylic acid (d-TAI-284) has been assigned to the sinister series by X-ray analysis. The conformation of d-TAI-284 was similar to that of indomethacin, which indicates that a hypothetical receptor site contour for indomethacin analogs proposed by Shen is also applicable to d-TAI-284. Importance of conformational structure in determining antiinflammatory activities is suggested.
- 公益社団法人日本薬学会の論文
- 1975-07-25
著者
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神谷 和秀
Central Research Division Takeda Chemical Industries Ltd.
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西川 正夫
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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神谷 和秀
Chemistry Research Laboratories Takeda Chemical Industries Ltd.
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和田 喜一
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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西川 正夫
Central Research Division Takeda Chemical Industries Ltd.
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和田 喜一
Central Research Division Takeda Chemical Industries Ltd.
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