Structures of Polymers formed in Aqueous Solutions of Cefsulodin Sodium

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概要

• 論文の詳細を見る

• Polymers of cefsulodin sodium (CFS) formed in aqueous solution were isolated by Sephadex G-25 gel filtration and purified by dialysis in Visking tubes. Their structures were investigated chemically and by ultraviolet, infrared and nuclear magnetic resonance spectroscopy. From the results, the following polymerization process is suggested : Opening of the β-lactam ring of CFS is followed by decarboxylation, and successive cleavage of the thiazine ring results in the formation of 2-(α-sulfophenylacetamido) acetaldehyde. Aldol condensation of this aldehyde may produce polymers. The polymerization may be terminated by reaction with the isonicotinamide group of CFS. This polymerization process is different from those of penicillins previously reported by several research groups.

• 社団法人日本薬学会の論文
• 1981-06-25

著者

• 青木 勇

  Central Research Division Takeda Chemical Industries Ltd.

• 水島 裕

  First Department Of Internal Medicine St. Marrianna University School Of Medicine

• 板倉 紘一

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 青木 勇

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 笠原 文子

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 西川 正夫

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 笠原 文子

  Central Research Division Takeda Chemical Industries Ltd.

• 西川 正夫

  Central Research Division Takeda Chemical Industries Ltd.

• 板倉 紘一

  Chemical Development Laboratories Central Research Division Takeda Chemical Industries Ltd.

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