Fused Pyrimidines. III. The Reaction of 2,4-Dichloroquinazoline with N-Alkyl Cyclic Amines

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概要

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• The reaction of 2,4-dichloroquinazoline with N-methylpyrrolidine gave N-(2-chloro-4-quinazolinyl)-N-methylpyrrolidinium chloride. This product, on being heated, gave 2-chloro-4-[N-(4-chlorobutyl)-N-methylamino]-quinazoline and it reacted with water in the presence of excess N-methylpyrrolidine to give a stable betaine, 4-(1-methyl-1-pyrrolidinio)-2-quinazolinolate. By using this reaction, several new 4-[N-alkyl-N-(ω-chloroalkyl) amino]-2-chloroquinazoline derivatives were prepared from 2,4-dichloroquinazoline and N-alkyl cyclic amines.

• 公益社団法人日本薬学会の論文
• 1982-10-25

著者

• 三木 秀樹

  Research Laboratories, Agricultural Chemicals Division, Takeda Chemical Industries, Ltd.

• 笠原 文子

  Central Research Division Takeda Chemical Industries Ltd.

• 三木 秀樹

  Research Laboratories Agricultural Chemicals Division Takeda Chemical Industries Ltd.

関連論文

• Structures of Polymers formed in Aqueous Solutions of Cefsulodin Sodium
• Fused Pyrimidines. IV. The Reaction of 4-Alkylthio-2-chloroquinazolines with Alkylamines in Dimethylformamide
• Fused Pyrimidines. III. The Reaction of 2,4-Dichloroquinazoline with N-Alkyl Cyclic Amines
• Fused Pyrimidines. II. Formation Mechanism of 2-[N-Alkyl-N-(ω-chloroalkyl) amino]-4-chloroquinazolines
• Fused Pyrimidines. I. The Chlorination of 2,4 (1H, 3H)-Quinazolinedione with Phosphoryl Chloride in the Presence of N-Alkylcyclic Amines

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