Fused Pyrimidines. IV. The Reaction of 4-Alkylthio-2-chloroquinazolines with Alkylamines in Dimethylformamide

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概要

• 論文の詳細を見る

• The reaction of 4-alkylthio-2-chloroquinazolines with alkylamines in dimethylformamide afforded 2,4-bis (alkylthio)-, 2-alkylamino-4-alkylthio-, 4-alkylamino-2-chloro-, 4-alkylamino-2-alkylthio-, and 2,4-bis (alkylamino) quinazolines. The relative easines of displacement of the chlorine and/or the alkylthio group in 4-alkylthio-2-chloroquinazolines depended on the bulkiness rather than the basicity of the alkylamine. A possible reaction mechanism is discussed.

• 社団法人日本薬学会の論文
• 1982-07-25

著者

• 山田 順二

  Research Laboratories Agricultural Chemicals Division Takeda Chemical Industries Ltd.

• 三木 秀樹

  Research Laboratories, Agricultural Chemicals Division, Takeda Chemical Industries, Ltd.

• 三木 秀樹

  Research Laboratories Agricultural Chemicals Division Takeda Chemical Industries Ltd.

関連論文

• Fused Pyrimidines. IV. The Reaction of 4-Alkylthio-2-chloroquinazolines with Alkylamines in Dimethylformamide
• Fused Pyrimidines. III. The Reaction of 2,4-Dichloroquinazoline with N-Alkyl Cyclic Amines
• Fused Pyrimidines. II. Formation Mechanism of 2-[N-Alkyl-N-(ω-chloroalkyl) amino]-4-chloroquinazolines
• Fused Pyrimidines. I. The Chlorination of 2,4 (1H, 3H)-Quinazolinedione with Phosphoryl Chloride in the Presence of N-Alkylcyclic Amines

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