Fused Pyrimidines. II. Formation Mechanism of 2-[N-Alkyl-N-(ω-chloroalkyl) amino]-4-chloroquinazolines

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概要

• 論文の詳細を見る

• 2,4 (1H, 3H)-Quinazolinedione readily undergoes a von Braun-type reaction with N-alkyl cyclic amines in phosphoryl chloride through the formation of 4-oxo-3,4-dihydroquinazolinyl dichlorophosphate and N-alkyl-N-(4-oxo-3,4-dihydro-2-quinazolinyl) cyclic ammonium chloride in sequence ; the latter decomposes to give a new tertiary amine, 2-[N-alkyl-N-(ω-chloroalkyl) amino]-4-chloroquinazolines. A possible reaction mechanism is discussed.

• 公益社団法人日本薬学会の論文
• 1982-09-25

著者

• 三木 秀樹

  Research Laboratories, Agricultural Chemicals Division, Takeda Chemical Industries, Ltd.

• 三木 秀樹

  Research Laboratories Agricultural Chemicals Division Takeda Chemical Industries Ltd.

関連論文

• Fused Pyrimidines. IV. The Reaction of 4-Alkylthio-2-chloroquinazolines with Alkylamines in Dimethylformamide
• Fused Pyrimidines. III. The Reaction of 2,4-Dichloroquinazoline with N-Alkyl Cyclic Amines
• Fused Pyrimidines. II. Formation Mechanism of 2-[N-Alkyl-N-(ω-chloroalkyl) amino]-4-chloroquinazolines
• Fused Pyrimidines. I. The Chlorination of 2,4 (1H, 3H)-Quinazolinedione with Phosphoryl Chloride in the Presence of N-Alkylcyclic Amines

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