Fused Pyrimidines. I. The Chlorination of 2,4 (1H, 3H)-Quinazolinedione with Phosphoryl Chloride in the Presence of N-Alkylcyclic Amines

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概要

• 論文の詳細を見る

• In the reaction of 2,4 (1H, 3H)-quinazolinedione with phosphoryl chloride in the presence of excess N-methylpyrrolidine, the hydroxy groups at the 2- and 4-position of the quinazoline nucleus were replaced by the N-methyl-4-chlorobutylamino group and chlorine to give 4-chloro-2-(N-methyl-4-chlorobutylamino) quinazoline in good yield. By using this reaction, several new 4-chloro-2-dialkylaminoquinazoline derivatives were obtained from N-alkylcyclic amines and 2,4 (1H, 3H)-quinazolinedione.

• 公益社団法人日本薬学会の論文
• 1982-06-25

著者

• 三木 秀樹

  Research Laboratories, Agricultural Chemicals Division, Takeda Chemical Industries, Ltd.

• 三木 秀樹

  Research Laboratories Agricultural Chemicals Division Takeda Chemical Industries Ltd.

関連論文

• Fused Pyrimidines. IV. The Reaction of 4-Alkylthio-2-chloroquinazolines with Alkylamines in Dimethylformamide
• Fused Pyrimidines. III. The Reaction of 2,4-Dichloroquinazoline with N-Alkyl Cyclic Amines
• Fused Pyrimidines. II. Formation Mechanism of 2-[N-Alkyl-N-(ω-chloroalkyl) amino]-4-chloroquinazolines
• Fused Pyrimidines. I. The Chlorination of 2,4 (1H, 3H)-Quinazolinedione with Phosphoryl Chloride in the Presence of N-Alkylcyclic Amines

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