Synthesis of Hydroquinone Monosulfates Having Carboxyalkyl and Hydroxyalkyl Side Chains

スポンサーリンク

概要

• 論文の詳細を見る

• Sulfate conjugates of ubiquinone metabolites (Ia, Ib) and related compounds including 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, Id-10) were synthesized. Chemical shifts in the proton nuclear magnetic resonance (^1H-NMR) spectra of the 1- and 4- sulfates were assigned by investigating differences in the low-field shifts between model compounds and the corresponding sulfates, and by regio-specific synthesis of the 4-sulfates.

• 公益社団法人日本薬学会の論文
• 1985-09-25

著者

• 水田 栄治

  Central Research Division, Takeda Chemical Industries, Ltd.

• 神谷 和秀

  Central Research Division Takeda Chemical Industries Ltd.

• 今田 伊助

  Central Research Division, Takeda Chemical Industries, Ltd.

• 神谷 和秀

  Chemistry Research Laboratories Takeda Chemical Industries Ltd.

• 岡本 加世子

  Central Research Division, Takeda Chemical Industries, Ltd.

• 今田 伊助

  Central Reseach Division Takeda Chemical Industries Ltd.

• 水田 栄治

  Central Research Division Takeda Chemical Industries Ltd.

• 岡本 加世子

  Central Reseach Division Takeda Chemical Industries Ltd.

関連論文

• 13.Aplysin 20およびPillaronone bromoacetateのX線法による構造研究
• Structure-Activity Study of Diuretic Azanaphthalene Derivatives
• Spirocyclopropane Compounds. V. One-Step Synthesis of 5-Acetylspiro [benzofuran-2 (3H), 1'-cyclopropan]-3-one
• Photochemical Reaction of 21-Methyl-20,21-diketosteroids : The Formation of New 3´, 4´, 16α, 17α-Tetrahydrocyclobut [16,17] androstanes
• 44 沢瀉の新トリテルペン化合物
• 1-Aryl-1-acetoxy-3-buteneのフラシュ熱閉環反応(第1報)
• 1,5-Benzoxathiepin Derivatives. III. Optical Resolution of Methyl (±)-cis-3-Hydroxy-4-[3-(4-phenyl-1-piperazinyl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate Hydrochloride ((±)-CV-5197) with Selective 5-Hydroxytryptamine_2(5-HT_2)-Antagonistic
• Synthesis of Hydroquinone Monosulfates Having Carboxyalkyl and Hydroxyalkyl Side Chains
• Structure of 6,3' : 6,5'-Dianhydro-5,5-dibromo-5,6-dihydro-6,6-dihydroxy-1-(β-D-xylofuranosyl) uracil
• 5-Hydroxy-1-(2-hydroxyethyl)-6,7,8-trimetlyl-2-thia-7-azabicyclo〔3,3,0〕octane Hemihydrateの結晶構造解析Thiamineのアルカリ分解物の構造
• X-Ray Analysis of an Aminoglycoside Antibiotic P-2563 (P) Monohydrobromide
• X-Ray Analysis of 9-Propionylmaridomycin III Iodo Adduct
• Struktur und Absolute Konfiguration von Diosbulbin-A, -B und -C. Die Kristallanalyse von 3-Bromo-2-oxo-tetrahydrodiosbulbin-A
• The Chemistry of Aminoglycoside Antibiotics from Pseudomonas fluorescence. III. Absolute Configuration of P-2563 (P) (Sorbistin A_1) and P-2563 (A) (Sorbistin B)
• The Chemistry of Aminoglycoside Antibiotics from Pseudomonas fluorescence. II. Absolute Configuration of the Diaminopolyol, the Aglycone of P-2563 (P) (Sorbistin A_1) and P-2563 (A) (Sorbistin B)
• Studies on Pillaromycin A. IV. The Structure of Pillaromycin A
• Synthesis of immunologically Active Muramyl Dipeptide Derivatives containing a Quinonyl Moiety via Aminoacyl Intermediates
• Novel Quinonyl Derivatives of Muramyl Dipeptide Possessing Potent Antitumor Activity
• Studies on the Alkaloids of Menispermaceous Plants. CCLIX. Alkaloids of Menispermum dauricum DC. (Suppl. 7). Structures of Acutumine and Acutumidine, Chlorine-Containing Alkaloids with a Novel Skeleton
• 8.Ubiquinone(35)の光反応とその生成物(第92回会議研究発表要旨)
• Crystal and Molecular Structure of Cefmenoxime Hemihydrochloride
• Crystal Structure of (±)-trans-2-Cyclobutylamino-5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthalenol Hydrobromide
• 51 新抗腫瘍性抗生物質Macbecin I及びIIの構造
• X-Ray Analysis of d-6-Chloro-5-cyclohexylindan-1-carboxylic Acid (d-TAI-284)
• Molecualr Structures of 8-Chloro-6-phenyl-4H-8-triazolo [4,3-a] [1,4] benzodiazepine, 2-Acetoxyamino-4-acetyl-8-chloro-3,4-dihydro-6-phenyl-1,4,5-benzotriazocine and 8-Chloro-4,11-diacetyl-4,11-dihydro-2-methyl-6-phenyloxazolo [4,5-b]-[1,4,5] benzotriazoc
• Semisynthetic β-Lactam Antibiotics. IV. The X-Ray Analysis of Monopotassium α-Sulfophenylacetate Monohydrate. The Configuration of the Acyl Side Chain of α-Sulfobenzylpenicillin
• The Structure of Aristeromycin
• Studies on Pillaromycin A. V. The X-Ray Analysis of Pillaronone Monobromoacetate
• Biological-Active Triterpenes of Alismatis Rhizoma. III. The X-Ray Crystallography of Alisol A (23,24)-Acetonide 11-Monobromoacetate
• X-Ray Analysis of Thiamine Propyl Disulfide
• 1.Thiamine anhydrideの幾何異性体(ビタミンB研究委員会 第187回会議研究発表要旨)
• X-Ray Analysis of an Unusual Amino Acid Isolated from the Hydrolysate of a New Antibiotic, Enduracidin
• O^6,2'-6-Hydroxycyclouridine
• The X-ray Analysis of Lenthionine, an Odorous Substance of Shiitake, an Edible Mushroom
• 3 新抗生物貭Tolypomycinの構造
• Synthesis, Metabolism, and in Vitro Biological Activities of 6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (CV-2619)-Related Compounds
• Effects of 6-(ω-Substituted Alkyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinones and Related Compounds on Mitochondrial Succinate and Reduced Nicotinamide Adenine Dinucleotide Oxidase Systems
• Spirocyclopropane Compounds. IV. Synthesis of 5-Acetylspiro-[benzofuran-2 (3H), 1'-cyclopropan]-3-one Related Compounds for Evaluation as Gastric Antisecretory and Antiulcer Agents
• Spirocyclopropane Compounds. III. Synthesis of Spiro [benzofuran-2 (3H), 1'-cyclopropan]-3-ones for Evaluation as Gastric Antisecretory and Antiulcer Agents
• Synthesis of Quinones having Carboxy- and Hydroxy-Alkyl Side Chains, and Their Effects on Rat-Liver Lysosomal Membrane
• ユビキノンの代謝と生理活性 : 日本ビタミン学会第30回大会シンポジウム(脂溶性ビタミンに関する最近の進歩)
• Ubiquinone and Related Compounds. XXXI. Synthesis of Urinary Metabolites of Ubiquinone, Phylloquinone, α-Tocopherol and Their Related Compounds
• Ubiquinone and Related Compounds. XXVII. Synthesis of Urinary Metabolites of Phylloquinone and α-Tocopherol
• Ubiquinone and Related Compounds. XXVIII. Effect of the Metabolites of α-Tocopherol, Phylloquinone and Ubiquinone on the Stability of Rat-liver Lysosomal Membrane
• Ubiquinone and Related Compounds. XXVI. The Urinary Metabolites of Phylloquinone and α-Tocopherol
• Nuclear Magnetic Resonance Studies of 2-Amino- and 2-Substituted Amino-5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthalenols
• ベンゾキノン関連化合物のエネルギー代謝および脂質過酸化反応に対する作用
• Effect of 6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (CV-2619) on Microsomal Lipid Peroxidation
• Spirocyclopropane Compounds. VI. : Synthesis of Spiro[benzo[b]-thiophene-2(3H), 1'-cyclopropan]-3-ones
• A Facile Synthesis of 1,4-Benzoquinones Having a Hydroxyalkyl Side Chain
• Ubiquinone and Related Compounds. XXXVIII. Biological Oxidation of Ubiquinone
• 2-II-15 ユビキノン代謝物及び関連化合物の硫酸抱合体の合成及びそれらの2,3の生理作用 : 第35回大会一般研究発表要旨 : 日本ビタミン学会
• Spirocyclopropane Compounds. I. Synthesis and Reactivity of Spiro [cyclopropane-1,2'-[2H] indol]-3'(1'H)-ones
• Ubiquinone関連化合物の化学
• Conformational Analysis of 1,1a, 6,10b-Tetrahydrodibenzo [b, f]-cycloprop [d] azepine Derivatives
• 16 新核酸系抗生物質Mildiomycinの化学構造
• Ubiquinone関連化合物のSlow reacting substance of anaphylaxis生成抑制作用
• Ubichinone und Verwandte Substanzen. VIII, Bilolgisches Verhalten des Ubichromenols (35) in Ratten
• Ubichinone und Verwandte Substanzen. VII. Quantitative Analyse der Ubichromenole
• Photochemical Reaction of Ubiquinone (35). VI. Coenzymatic Activity of Ubiquinone (35) and Related Compounds
• Photochemical Reaction of Ubiquinone (35). V. Synthesis of 2-Hydroxy-3-methoxy-5-methyl-6-phytyl-p-benzoquinone
• Photochemical Reaction of Ubiquinone (35). IV. Formation of Demethylubiquinone (35)
• Photochemical Reaction of Ubiquinone (35).III. Formation of Isoubiquinone (35)
• Photochemical Reaction of Ubiquinone (35). II. Formation of Ubichromenol (35)
• Photochemical Reaction of Ubiquinone (35). I. Photochemical Reaction of Ubiquinone (35)
• Photochemische Reaktion von Ubichinon (35). II. Uber Ubichromenol (35) und Isoubichinon (35)
• The Absolute Configuration of P-1894B, A Potent Prolyl Hydroxylase Inhibitor
• Chemistry of Toromycin
• 複素環化合物の研究(第4報) 2-(2,6-Dichlorobenzylidenehydrazino)-1,4,5,6-tetrahydropyrimidine Hydrochlorideおよび関連ヒドラゾン化合物の幾何異性体

もっと見る 閉じる

スポンサーリンク