The Absolute Configuration of P-1894B, A Potent Prolyl Hydroxylase Inhibitor

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概要

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• The previous X-ray-crystallographic determination of the relative configuration of P-1894B, a potent prolyl hydroxylase inhibitor isolated from the culture broth of Streptomyces albogriseolus, was extended by means of chemical and spectral studies. The absolute configuration of P-1894B (1) was established from the absolute configuration of two constituent monosaccharides, L-aculose (3) and L-rhodinose (4), produced by chemical degradation of 1. The absolute configuration of the aglycone part (aquayamycin) was also established as 2. The stereostructure of the reduction product (11) obtained by the catalytic hydrogenation of 1 was also elucidated.

• 公益社団法人日本薬学会の論文
• 1984-11-25

著者

• 水田 栄治

  Central Research Division, Takeda Chemical Industries, Ltd.

• 貴志 豊和

  Central Research Division Takeda Chemical Industries Ltd.

• 貴志 豊和

  武田薬品研究所

• 水田 栄治

  Central Research Division Takeda Chemical Industries Ltd.

• 水田 栄治

  武田薬品中央研究所

• 岡崎 尚良

  Central Research Division, Takeda Chemical Industries, Ltd.

• 岡崎 尚良

  Central Research Division Takeda Chemical Industries Ltd.

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