Stereochemical Interrelationship between Maridomycin and Leucomycin
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概要
- 論文の詳細を見る
Epoxidation of 18-dihydroleucomycin A_s (5) with m-chloroperbenzoic acid afforded 18-dihydromaridomycin II (6). Conversion of leucomycin A_s (1) into maridomycin II (2) was also accomplished in a similar process. This evidence together with the result of X-ray analysis of 9-propionylmaridomycin III has finally confirmed the absolute stereochemistry of leucomycin A_s. In addition, Δ^2-9-epi-18-dihydromaridomycin III (12) was prepared by the NaBH_4 reduction of 9-dehydromaridomycin III (11) and the effect of the C-9 hydroxyl group on optical rotations was discussed.
- 公益社団法人日本薬学会の論文
- 1978-09-25
著者
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室井 正之
武田薬品中央研究所
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貴志 豊和
武田薬品研究所
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貴志 豊和
Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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室井 正之
Microbiological Research Laboratories, Central Research Division Takeda Chemical Industries, Ltd.
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