Maridomycin, a New Macrolide Antibiotic. XII. A Simple Quantitative Analysis of 9-Propionylmaridomycin Components
スポンサーリンク
概要
- 論文の詳細を見る
Macrolide antibiotic producing organisms produce usually several homologous components. A quantitative analysis of these components has not been reported because of their physicochemical similarity. A method for quantitative analysis of a mixture of macrolide components was established by the use of thin-layer chromatography and ultraviolet (UV) absorption spectrometry. 9-Propionylmaridomycin which has no absorption maximum in UV and visible region was converted into its thiosemicarbazone exhibiting an absorption maximum at 271nm. The thiosemicarbazones formed are separated by silica gel thin-layer chromatography using a solvent system of hexane-isopropyl ether-EtOH-H_2O (1 : 4 : 3 : 2). The composition ratio of each component was calculated from the absorbance of each extract of separated fraction. By this method recovery rate was almost quantitative.
- 公益社団法人日本薬学会の論文
- 1975-12-25
著者
-
室井 正之
武田薬品中央研究所
-
川村 邦夫
Quality Control Department Osaka Plant
-
貴志 豊和
武田薬品研究所
-
貴志 豊和
Medicinal Research Laboratories, Central Research Division, Takeda Chemical and Industries, Ltd.
-
国重 信夫
Takeda Chemical Industries, Ltd.
-
室井 正之
Takeda Chemical Industries, Ltd.
-
国重 信夫
Takeda Chemical Industries Ltd.
関連論文
- Application of Chromatography. XLI. Behavior of Diaminouracil Derivatives.
- Application of Chromatography. XXXIX. Biosynthesis of Riboflavin. (3).
- Application of Chromatography. XXXVIII. Total Synthesis of 6-Methyl-7-hydroxyribolumazine.
- Application of Chromatography. XXXVII. Total Synthesis of 6,7-Dimethylribolumazine.
- Application of Chromatography. XXXVI. Biosynthesis of Riboflavin. (2). Riboflavin-synthesizing Enzyme extracted from Eremothecium ashbyii.
- Application of Chromatography. XXXV. On the Biochemical Significance of 6-Methyl-7-hydroxyribolumazine in the Culture of Eremothecium ashbyii.
- On the Nomenclature of the Fluorescent Substances produced in the Culture of Eremothecium ashbyii
- 71.Eremothecium ashbyiiの生産するV化合物(6-Methyl-7-hydroxy-ribolumazine)の生成機構(第10回大会研究発表要旨)
- 6.V物質の構造(第99回協議会研究発表要旨)
- 2.Eremothecium ashbyiiの生産するV物質の構造(第96回協議会研究発表要旨)
- 51 新抗腫瘍性抗生物質Macbecin I及びIIの構造
- The Structure of Aristeromycin
- 3 新抗生物貭Tolypomycinの構造
- Application of Chromatography. XXXIV. Structure of the Purple Fluorescent Substance produced by Eremothecium ashbyii.
- Structure of V-Compound produced by Eremothecium Ashbyii
- Application of Chromatography. XXXIII. V-Compound Isolated from the Mycelium of Eremothecium ashbyii.
- Synthesis of Polyhydroxysteroids. V. Preparation and Infrared Spectra of 16β, 20α-Isopropylidenedioxysteroids.
- Synthesis of Polyhydroxy-steroids. II. Syntheses of Isomeric 5α-Pregnane-3,5,6,16,20-pentols and Related Compounds.
- Maridomycin, a New Macrolide Antibiotic. XI. The Structures of Maridomycin Components
- Maridomycin, a New Macrolide Antibiotic. X. The Structure of Maridomycin II
- Maridomycin, a New Macrolide Antibiotic. XII. A Simple Quantitative Analysis of 9-Propionylmaridomycin Components
- Mechanism of a New Color Reaction of Aminopyrine and Its Application to Determination of Ammonia
- 16 新核酸系抗生物質Mildiomycinの化学構造
- Studies on Lankacidin-Group (T-2636) Antibiotics. V. Chemical Structures of Lankacidin-Group Antibiotics. (1)
- The Absolute Configuration of P-1894B, A Potent Prolyl Hydroxylase Inhibitor
- Stereochemical Interrelationship between Maridomycin and Leucomycin
- 19.Alstonia alkaloid "Macralstonine"の構造研究