Synthetic Studies on Condensed-Azole Derivatives. II. Application of a Computer-Assisted Automated Synthesis Apparatus for the Synthesis of N-Substituted Sulfamoylpropylthioimidazo[1,2-b]pyridazines
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概要
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For the purpose of improving the anti-asthmatic activity of 3-(imidazo[1,2-b]pyridazin-6-yl)thiopropanesulfon-amide (I), the computer-assisted automated synthesis apparatus developed at Takeda was used to modify the sulfon-amide moiety of I. Several kinds of sulfonamide derivatives (1-24) were easily obtained, confirming the usefulness of the automated synthesis apparatus in the laboratory. Anti-asthmatic activity of these derivatives was examined in a platelet activating factor (PAF)-induced bronchoconstriction. Among them, the piperidino-piperidine derivative (13) was found to possess comparable activity to that of I.
- 1995-09-15
著者
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桑原 雅明
Pharmaceutical Research Division, Pharmaceutical Research Laboratories III Takeda Chemical Industrie
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加藤 真二
Research Promotion, Takeda Chemical Industries, Ltd.,
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菅原 徹
Research Promotion, Takeda Chemical Industries, Ltd.,
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三宅 昭夫
Pharmaceutical Research Division, Pharmaceutical Research Laboratories III Takeda Chemical Industrie
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加藤 真二
Research Promotion Takeda Chemical Industries Ltd.
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菅原 徹
Molecular Chemistry Laboratory, Takeda Chemical Industries Ltd.,
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三宅 昭夫
武田薬品・創薬研究本部
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桑原 雅明
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industries
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Kato Shinji
Research Promotion Takeda Chemical Industries Ltd.
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菅原 徹
Molecular Chemistry Laboratory Takeda Chemical Industries Ltd.
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Miyake Akio
Pharmaceutical Research Division Pharmaceutical Research Laboratories Ii Research Promotion Takeda C
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Kuwahara Masaaki
Pharmaceutical Research Division Pharmaceutical Research Laboratories Ii Research Promotion Takeda C
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