Synthesis of Dibenzo [b, f] cycloprop [d] azepine Derivatives. I. Introduction of a Cyclopropane Ring by the Use of Simmons-Smith Reagent
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概要
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The Simmons-Smith reaction of 5H-dibenz [b, f] azepine (4) and 5-methyl-5H-dibenz-[b, f] azepine (5) yielded 1,1a, 6,10b-tetrahydro-6-methyldibenzo [b, f] cycloprop [d] azepine (6), which represents synthesis of a novel condensed ring system. 6 was demethylated via the formamide derivative 7 to give 1,1a, 6,10b-tetrahydrodibenzo [b, f] cycloprop [d]-azepine (8), which was converted into pharmacologically active 6-dialkylaminoalkyl (9) and 6-carbamoyl (17) derivatives. Cyclopropanation of 5-(3-halopropyl)-5H-dibenz [b, f] azepines (11) with the Simmons-Smith reagent, however, led to additional reactions in the side chain to yield 12,13,14,and 15.
- 社団法人日本薬学会の論文
- 1976-11-25
著者
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川野 泰彦
Central Research Division Takeda Chemical Industries Ltd.
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川島 健也
Central Research Division, Takeda Chemical Industries, Ltd.
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川島 健也
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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川野 泰彦
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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川島 健也
Central Research Division Takeda Chemical Industries Ltd.
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