Studies on Antidiabetic Agents. III. 5-Arylthiazolidine-2,4-diones as Potent Aldose Reductase Inhibitors
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概要
- 論文の詳細を見る
Thiazolidine-2,4-dione derivatives having one or two substituent (s) such as phenyl, heteryl and alkyl group (s) at the 5-position were synthesized and evaluated as aldose reductase inhibitors. Inhibition by the active compounds of the swelling of the lens in a rat-lens-culture assay was also measured. Among these compounds, a series of 5-(3,4-dialkoxyphenyl) thiazolidine-2,4-diones showed pronounced activities in both assays. Structure-activity relationships are discussed and a new approach to the synthesis of 5-arylthiazolidine-2,4-diones is described.
- 公益社団法人日本薬学会の論文
- 1982-10-25
著者
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水野 克利
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.
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川松 豊
Central Research Division, Takeda Chemical Industries, Ltd.,
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目黒 寛司
浜理薬品工業株式会社
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今宮 栄光
Central Research Division, Takeda Chemical Ind., Ltd.,
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水野 克利
Central Research Division, Takeda Chemical Ind., Ltd.,
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水野 克利
Chemistry Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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左右田 隆
武田薬品工業株式会社医薬研究本部
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川松 豊
干寿製薬株式会社経営戦略室
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目黒 寛司
Central Research Division, Takeda Chemical Industries, Ltd.,
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多和田 紘之
Central Research Division, Takeda Chemical Industries, Ltd.,
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左右田 隆
Central Research Division, Takeda Chemical Industries, Ltd.
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山本 佑二郎
Senju Pharmaceutical Co., Ltd.,
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今宮 栄光
Resarch & Development Division Takeda Chemical Industries Ltd.
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多和田 紘之
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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山本 佑二郎
Senju Pharmaceutical Co. Ltd.
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