Heterocycles. XIV. Reactions of 2-Amino-5-phenyl-1,4-benzodiazepines and 2-Amino-6-phenyl-1,5-benzodiazocines with Diketene
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概要
- 論文の詳細を見る
The reaction of 2-amino-1,5-benzodiazocines (1) with diketene (2) gave two isomeric products 3 and 4,whereas 2-amino-1,4-benzodiazepines (16) afforded 2-acetoacetamidodiazepines (17). Treatment of the acetoacetylated derivatives (3,4,17) with methanolic hydrogen chloride or thionyl chloride afforded the corresponding fused pyrimidine derivatives (5,6,18). Thermal dehydration of both 3a and 4a, on the other hand, gave the same cyclized compound (5a), indicating that acyl migration took place in the reaction of 4a. Similarly, 17a gave the rearranged product (19a).
- 公益社団法人日本薬学会の論文
- 1979-12-25
著者
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目黒 寛司
浜理薬品工業株式会社
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目黒 寛司
Central Research Division, Takeda Chemical Industries, Ltd.,
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夏苅 英昭
Central Research Division, Takeda Chemical Industries, Ltd.
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桑田 胖
Central Research Division, Takeda Chemical Industries, Ltd.
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夏苅 英昭
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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桑田 胖
Central Research Division Takeda Chemical Industries Ltd.
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