Heterocycles. XII. Synthesis of 2-Amino-5-phenyl-1,4-benzodiazepine 1-Oxides and 2-Amino-6-phenyl-1,5-benzodiazocine 1-Oxides and Their Reactions with Acylating Agents
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概要
- 論文の詳細を見る
When 2-amino-3,4-dihydro-6-phenyl-1,5-benzodiazocines (1) and 2-amino-5-phenyl-3H-1,4-benzodiazepines (5) were treated with m-chloroperbenzoic acid, oxidation occurred selectively at the 1-position giving the corresponding 1-oxides (2 and 6), which are a novel class of derivatives of the diazocines and the diazepines. Although reaction of 2 with phosgene afforded the oxadiazolone derivative (4) in high yield, rearrangement of the diazepine oxide (6) occurred upon treatment with phosgene in the presence of imidazoles to form the 3-imidazolyl compound (9). When 6a was treated with acetic anhydride, rearrangement also occurred to give the 3-oxo compound (8).
- 公益社団法人日本薬学会の論文
- 1979-11-25
著者
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目黒 寛司
浜理薬品工業株式会社
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目黒 寛司
Central Research Division, Takeda Chemical Industries, Ltd.,
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夏苅 英昭
Central Research Division, Takeda Chemical Industries, Ltd.
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桑田 胖
Central Research Division, Takeda Chemical Industries, Ltd.
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夏苅 英昭
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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桑田 胖
Central Research Division Takeda Chemical Industries Ltd.
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