Heterocycles. XIII. Reactions of 2-Amino-1,4-benzodiazepine 1-Oxides and 2-Amino-1,5-benzodiazocine 1-Oxides with Acetylenecarboxylates
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概要
- 論文の詳細を見る
The reaction of 2-amino-1,5-benzodiazocine 1-oxides (1) with acetylenecarboxylates (2,11) afforded C_<(10)>-alkylated derivatives (3) via 3,3-sigmatropic rearrangement. Compounds 3 gave 10-alkoxycarbonylmethyl-1,5-benzodiazocines (4) when heated in ethanol. Heating of 3a-e in pyridine, on the other hand, gave indole derivatives (9), which were converted into 7-benzoylindoles (10a-e) by acid hydrolysis. The reaction of 2-amino-1,4-benzodiazepine 1-oxides (13) with acetylenedicarboxylates (11) also gave the rearranged products (14).
- 公益社団法人日本薬学会の論文
- 1979-11-25
著者
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夏苅 英昭
Central Research Division, Takeda Chemical Industries, Ltd.
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桑田 胖
Central Research Division, Takeda Chemical Industries, Ltd.
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夏苅 英昭
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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桑田 胖
Central Research Division Takeda Chemical Industries Ltd.
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