BIOLOGICAL STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES : IV. ACUTE, SUBACUTE AND CHRONIC TOXICITY STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES IN MICE, RATS, DOGS AND MONKEYS
スポンサーリンク
概要
- 論文の詳細を見る
It has been demonstrated that cholestane-3β, 5α, 6β-triol (CT) and its derivatives show remarkably preventing effects on the development of the experimental hypercholesterolemia and atherosclerosis in cholesterol-fed-rabbits, rats and chickens, and that the compounds lower the elevated lipemia caused by oral administration of the vegetable oil in rats (1). Their effects on the metabolic fate of cholesterol have been investigated (2). The present experiments are the preclinical studies of the compounds including acute, subacute and chronic toxicities in mice, rats, dogs and monkeys.
- 社団法人 日本薬理学会の論文
著者
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今井 祥雄
Biological Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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梶原 彊
武田薬品工業株式会社研究所
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梶原 彊
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd
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横谷 肇
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd
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荻原 重男
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd
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荒蒔 義知
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd
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梶原 彊
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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今井 祥雄
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
-
横谷 肇
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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荻原 重男
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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- BIOLOGICAL STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES : IV. ACUTE, SUBACUTE AND CHRONIC TOXICITY STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES IN MICE, RATS, DOGS AND MONKEYS
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