HYPOCHOLESTEROLEMIC EFFECT OF ALISOL A-24-MONO-ACETATE AND ITS RELATED COMPOUNDS IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The rhizoma of <I>Alisma Plantago-aquatica L. var. orientate Samuels</I> used as a component of various preparations of Chinese medicine has long been accepted to have a diuretic effect. The availability of this plant as a pulver in the preparations is a good contrast concerning the presence of practically water insoluble triterpenes to many of the raw plants usually used as a decoctum. Several years ago the extract of this plant with organic solvents was demonstrated to exert a lipotropic effect, which was somewhat different in mode of action from those of other lipotropic agents (1), Further chemical studies on this extract succeeded to isolate the active triterpenes including alisol A-24-monoacetate (ALMA) and its related compounds (2, 3). The present paper describes mainly the hypocholesterolemic activity in the rats maintained on an atherogenic diet.
- 社団法人 日本薬理学会の論文
著者
-
今井 祥雄
Biological Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
-
松村 晴希
Biological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
-
荒蒔 義知
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd
-
松村 晴希
Biological Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
-
松村 晴希
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
-
今井 祥雄
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
関連論文
- Studies on the Syntheses of N-Heterocyclic Compounds. IV. Hypocholesterolemic 1,2,4-Oxadiazole Derivatives. (2)
- Studies on the Synthese of N-Heterocyclic Compounds. III. Hypocholesterolemic 1,2,4-Oxadiazole Derivatives (1)
- BIOLOGICAL STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES : IV. ACUTE, SUBACUTE AND CHRONIC TOXICITY STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES IN MICE, RATS, DOGS AND MONKEYS
- Biological-Active Triterpenes of Alismatis Rhizoma. I. Isolation of the Alisols
- The Antiscorbutic Activity of Some O-Benzoyl Derivatives of L-Ascorbic Acid in Guinea Pigs
- ELECTROLYTE PATTERN OF THE AORTA IN THE SPONTANEOUSLY HYPERTENSIVE RATS
- DEPRESSOR RESPONSES OF THE SPONTANEOUSLY HYPER-TENSIVE RATS TO THE ANTI-HYPERTENSIVE AGENTS
- SYSTEMIC EDEMA, THROMBOSIS, AND OTHER HYPER-TENSIVE LESIONS OBSERVED IN THE SPONTANEOUSLY HYPERTENSIVE RAT AT ADVANCED AGE
- THE ANTISCORBUTIC ACTIVITY OF L-ASCORBIC ACID PHOSPHATE GIVEN ORALLY AND PERCUTANEOUSLY IN GUINEA PIGS
- HYPOCHOLESTEROLEMIC EFFECT OF ALISOL A-24-MONO-ACETATE AND ITS RELATED COMPOUNDS IN RATS
- FURTHER OBSERVATIONS ON THE ANTISCORBUTIC ACTIVITY OF O-BENZOYL DERIVATIVES OF L-ASCORBIC ACID IN GUINEA PIGS
- NEREISTOXIN AND ITS DERIVATIVES, THEIR NEUROMUSCULAR BLOCKING AND CONVULSIVE ACTIONS
- CARDIOVASCULAR ACTION OF MESOIONIC COMPOUNDS, 3-SUBSTITUTED SYDNONIMINES
- THE POTENTIATION OF THE CORONARY DILATING AND THE CARDIAC ACTION OF ADENOSINE OR ADENINE NUCLEOTIDES BY METHYLHESPERIDIN