DEPRESSOR RESPONSES OF THE SPONTANEOUSLY HYPER-TENSIVE RATS TO THE ANTI-HYPERTENSIVE AGENTS
スポンサーリンク
概要
- 論文の詳細を見る
A variety of experimental hypertensions in rats has been available for the evaluation of the anti-hypertensive agents as well as for the mechanism studies of essential hypertension. The spontaneously hypertensive (SH) rat with 100 per cent incidence of heredity has been separated from the Wistar rats (1). Though the hypertension develops in the early stage without certain etiology, the animals in the advanced stage exhibit the vascular lesions such as periarteritis nodosa, nephrosclerosis and cardiac lesions (2-5). Recently, Okamoto <I>et al</I>. (6, 7) and Matsumoto (8) have indicated further some involvement of neural factors in development and maintenance of the hypertension.<BR> In order to elucidate pharmacologically the mode of the hypertension in the SH rats, the depressor responses to the anti-hypertensive agents were observed comparatively between in the SH and normotensive (N) rats.
- 社団法人 日本薬理学会の論文
著者
-
荒蒔 義知
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd
-
永岡 明伸
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd
-
菊地 健三
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd
-
菊地 健三
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
関連論文
- BIOLOGICAL STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES : IV. ACUTE, SUBACUTE AND CHRONIC TOXICITY STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES IN MICE, RATS, DOGS AND MONKEYS
- ELECTROLYTE PATTERN OF THE AORTA IN THE SPONTANEOUSLY HYPERTENSIVE RATS
- DEPRESSOR RESPONSES OF THE SPONTANEOUSLY HYPER-TENSIVE RATS TO THE ANTI-HYPERTENSIVE AGENTS
- SYSTEMIC EDEMA, THROMBOSIS, AND OTHER HYPER-TENSIVE LESIONS OBSERVED IN THE SPONTANEOUSLY HYPERTENSIVE RAT AT ADVANCED AGE
- THE ANTISCORBUTIC ACTIVITY OF L-ASCORBIC ACID PHOSPHATE GIVEN ORALLY AND PERCUTANEOUSLY IN GUINEA PIGS
- HYPOCHOLESTEROLEMIC EFFECT OF ALISOL A-24-MONO-ACETATE AND ITS RELATED COMPOUNDS IN RATS
- FURTHER OBSERVATIONS ON THE ANTISCORBUTIC ACTIVITY OF O-BENZOYL DERIVATIVES OF L-ASCORBIC ACID IN GUINEA PIGS
- NEREISTOXIN AND ITS DERIVATIVES, THEIR NEUROMUSCULAR BLOCKING AND CONVULSIVE ACTIONS
- HYPOTENSIVE ACTION OF N-ETHOXYCARBONYL-3-MORPHOLINOSYDNONIMINE, SIN-10
- CARDIOVASCULAR ACTION OF MESOIONIC COMPOUNDS, 3-SUBSTITUTED SYDNONIMINES
- CORONARY COLLATERAL VASODILATOR ACTION OF N-ETHOXYCARBONYL-3-MORPHOLINOSYDNONIMINE (SIN-10) IN HEART WITH CHRONIC CORONARY INSUFFICIENCY IN DOGS
- THE POTENTIATION OF THE CORONARY DILATING AND THE CARDIAC ACTION OF ADENOSINE OR ADENINE NUCLEOTIDES BY METHYLHESPERIDIN