CORONARY COLLATERAL VASODILATOR ACTION OF N-ETHOXYCARBONYL-3-MORPHOLINOSYDNONIMINE (SIN-10) IN HEART WITH CHRONIC CORONARY INSUFFICIENCY IN DOGS

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概要

• 論文の詳細を見る

• Effects of the sydnonimine derivatives on cardiovascular system have been studied (1-5), and the results in our laboratory are summarized as follows: <I>1</I>) the substitution by the group containing nitrogen with —N—N—linkage in the 3-position (SIN-series) showed vasodilator and consequently hypotensive effects resembling to those of nitrites, and <I>2</I>) N-acylation of imino group of sydnonimine made the compounds stable chemically (6), which probably resulted in gradual development and prolongation of the hypotensive effects as well as in decreased toxicity (4). These findings prompted us to study the effects of the derivatives on coronary collateral circulation, because nitroglycerin, the most important antianginal agent, was reported to dilate the collateral vessels which developed as a result of chronic myocardial ischem:ia (7, 8), and because the effects of agents on the collateral circulation have received considerable attention as one of the approaches to evaluate antianginal activity in laboratory experiment (9).<BR> The present study was carried out to investigate the effects of N-ethoxycarbonyl-3-morpholinosydnonimine (SIN-10) and related compounds on the coronary collateral circulation.

• 公益社団法人 日本薬理学会の論文

著者

• 菊地 健三

  Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd

• 平田 稔

  Biological Research Laboratories, Takeda Chemical Industries, Ltd.

関連論文

• ELECTROLYTE PATTERN OF THE AORTA IN THE SPONTANEOUSLY HYPERTENSIVE RATS
• DEPRESSOR RESPONSES OF THE SPONTANEOUSLY HYPER-TENSIVE RATS TO THE ANTI-HYPERTENSIVE AGENTS
• HYPOTENSIVE ACTION OF N-ETHOXYCARBONYL-3-MORPHOLINOSYDNONIMINE, SIN-10
• CARDIOVASCULAR ACTION OF MESOIONIC COMPOUNDS, 3-SUBSTITUTED SYDNONIMINES
• CORONARY COLLATERAL VASODILATOR ACTION OF N-ETHOXYCARBONYL-3-MORPHOLINOSYDNONIMINE (SIN-10) IN HEART WITH CHRONIC CORONARY INSUFFICIENCY IN DOGS
• THE POTENTIATION OF THE CORONARY DILATING AND THE CARDIAC ACTION OF ADENOSINE OR ADENINE NUCLEOTIDES BY METHYLHESPERIDIN

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