Asymmetric Reductive Aldol-Type Reaction with Carbonyl Compounds Using Dialkyl Tartrate as a Chiral Ligand

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概要

• 論文の詳細を見る

• An asymmetric reductive aldol-type reaction of α,β-unsaturated esters with carbonyl compounds using Rh catalyst and Et2Zn was investigated. A chiral zinc complex from α,β-unsaturated ester was easily generated as the key intermediate from Et2Zn and Wilkinson's catalyst with diisopropyl L-(+)-tartrate to give a variety of enantioenriched β-hydroxy esters. The reaction was also applied to the intramolecular reductive aldol cyclization.

• 公益社団法人 日本薬学会の論文

著者

• OMOTE Masaaki

  Faculty of Pharmaceutical Sciences

• ANDO Akira

  Faculty of Pharmaceutical Sciences

• SATO Kazuyuki

  Faculty of Pharmaceutical Sciences, Setsunan University

• Tarui Atsushi

  Faculty Of Pharmaceutical Sciences Setsunan University

• Tokura Yoriko

  Faculty of Pharmaceutical Sciences, Setsunan University

• Isoda Motoyuki

  Faculty of Pharmaceutical Sciences, Setsunan University

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• Asymmetric Reductive Aldol-Type Reaction with Carbonyl Compounds Using Dialkyl Tartrate as a Chiral Ligand

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