Effect of Mizoribine on Effector T Cell-Mediated Immune Responses in Mice

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概要

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• T cells play a principal role in cellular immunity and govern the regulatory mechanism in humoral immunity. Therefore, T cells play a key role as either effectors or regulators in the immune network. Mizoribine (MZR), an immunosuppressive agent, suppresses both humoral and cellular immunity by acting on both T cells and B cells. In this study, we examined the effect of MZR on various effector T cell-mediated immune responses in mice. MZR prolonged skin graft survival and suppressed a localized graft-versus-host reaction (GvHR) and sheep red blood cell (SRBC)-induced delayed-type hypersensitivity (DTH) reaction. In a collagen-induced arthritic mice model, MZR reduced the arthritic index and the swelling of the hind limbs. Furthermore, MZR suppressed both bone damage and histopathological changes in the hind limbs. Interestingly, MZR markedly suppressed the DTH reaction to type II collagen (CII) but had no effect on anti-CII antibody levels in this arthritic model. In these models, effector T cells such as cytotoxic T lymphocyte (CTL) and T_<DTH> cell play an important part in the development of these reactions. It is suggested that MZR inhibited these reactions via the inhibition of the effector T cell-mediated immune response. Therefore, it is also suggested that the suppressive effect of MZR on clinical rejection and autoimmune disease is based on its suppression of the effector T cell-mediated immune response, that is cellular immunity, in addition to humoral immunity.

• 社団法人日本薬学会の論文
• 1996-09-15

著者

• Inoue Naoki

  Department of Cardiovascular Medicine, Hokkaido University

• NAGAI Hiroichi

  Department of Pharmacology, Gifu Pharmaceutical University

• KAMADA Hiroyuki

  Department of Pharmacology, Gifu Pharmaceutical University

• TAKAOKA Yuko

  Department of Pharmacology, Gifu Pharmaceutical University

• NAKAGAMI Keiji

  Laboratory for Immunology, Institute for Life Science Research, Asahi Chemical Industry Co., Ltd.,

• MORI Hiroshi

  Department of Pharmacology, Gifu Pharmaceutical University

• Inoue Naoki

  Department Of Cardiovascular Medicine Hokkaido University

• Mori Hiroshi

  Department Of Architecture Graduate School Of Engineering Nagoya University

• Nakagami K

  Institute For Life Science Research Asahi Chemical Industry Co. Ltd.

• Nakagami Keiji

  Laboratory For Immunology Institute For Life Science Research Asahi Chemical Industry Co. Ltd.

• Nagai Hiroichi

  Department Of Clinical Pharmacology Gifu Pharmaceutical University

• Takaoka Yuko

  Department Of Pharmacology Gifu Pharmaceutical University

• Inoue Naoki

  Department Of Applied Physics Faculty Of Engineering Osaka University

• Inagaki Naoki

  Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Information Science Gifu University

• Mori Hiroshi

  Department Of Applied Physics Okayama University Of Science

• Nagai Hiroichi

  Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama

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