Pharmacological Study of Phospholipase A_2-Induced Histamine Release from Rat Peritoneal Mast Cells
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概要
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The effect of some drugs on phospholipase A_2 (PLA_2)-induced histamine release from rat peritoneal mast cells was investigated. 1. PLA_2 (Naja naja) caused the release of histamine from rat peritoneal mast cells in a dose related fashion. 2. The release of histamine by PLA_2 was decreased by the removal of each of calcium and glucose from the reaction medium (Tyrode's solution). 3. p-Bromophenacyl bromide and mepacrine, PLA_2 inhibitors, inhibited the release of histamine caused by PLA_2. 4. Cinnarizine and nifedipine, calcium channel blockers, and oxatomide, KC-404,tranilast and disodium cromoglycate, anti-allergic agents, also inhibited the PLA_2-induced histamine release. 5. When prednisolone (0.5 mg/kg) was administered i.p. 2,3 and 4h prior to the harvest of the mast cells, the amount of histamine released by PLA_2 ex vivo was significantly decreased. Hydrocortisone, prednisolone and dexamethasone clearly inhibited the release of histamine from mast cells when they were administered 4h prior to harvest of the cells.
- 公益社団法人日本薬学会の論文
著者
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Matsuura Naosuke
岐阜薬科大学 薬理
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INAGAKI Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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FUKUTOMI Osamu
Department of Pediatrics, Gifu University School of Medicine
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Inagaki N
Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University
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SAKAMOTO Tatsuo
Department of Pediatrics, Nagoya University School of Medicine
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Inagaki Naoki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Choi Soo
Department Of Forest And Forest Products Sciences Fuculty Of Agriculture Kyushu Unviversity
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MATSUURA NAOSUKE
Department of Pharmacology, Gifu College of Pharmacy
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KODA AKIHIDE
Department of Pharmacology, Gifu College of Pharmacy
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Sakurai Toshimi
Department Of Pharmacology Gifu Pharmaceutical University
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Fukutomi Osamu
Department Of Pediatrics Gifu University School Of Medicine
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Sakamoto Tatsuo
Department Of Pediatrics Nagoya University Graduate School Of Medicine
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Choi Soo
Department Of Anesthesiology And Pain Medicine Samsung Medical Center Sungkyunkwan University School
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Choi Soo
Department Of Advanced Materials Engineering (polymerics Program) Korea Advanced Institute Of Scienc
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Inagaki Naoki
Immunopharmacology Field Of Biofunctional Control Medical Information Science Division United Graduate School Of Drug Discovery And Medical Information Sciences Gifu University
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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