Effect of CV-3988,a Specific Antagonist against Platelet Activating Factor, on Homologous Passive Cutaneous Anaphylaxis in the Mouse Ear

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概要

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• Effect of CV-3988,a specific antagonist against platelet activating factor (PAF), on homologous passive cutaneous anaphylaxis (PCA) elicited in the mouse ear was investigated. PAF caused a potent increase in vascular permeability in the mouse ear. The potency was slightly lower than that of serotonin but higher than those of histamine, leukotriene (LT) C_4,LTD_4,prostaglandin (PG) E_1 and PGE_2 on a weight basis. The increased vascular permeability caused by PAF was inhibited by CV-3988 in a dose-dependent manner. CV-3988 did not affect the increase in vasular permeability caused by histamine or serotonin. IgG1 antibody-mediated PCA in the mouse ear was inhibited by CV-3988,although it did not affect IgE antibody-mediated PCA. These results suggest a possibility that PAF might be involved in IgG1 antibody-mediated PCA in the mouse.

• 公益社団法人日本薬学会の論文

著者

• Miura T

  Pharmaceutical Development Laboratory And Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.

• Miura Toru

  Department of Biology, Graduate School of Arts and Sciences, University of Tokyo

• INAGAKI Naoki

  Department of Pharmacology, Gifu Pharmaceutical University

• NAGAI Hiroichi

  Department of Pharmacology, Gifu Pharmaceutical University

• Inagaki N

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• Inagaki Naoki

  Department Of Electrical And Computer Engineering Nagoya Institute Of Technology

• Miura Toru

  Department Of Biology University Of Tokyo

• KODA AKIHIDE

  Department of Pharmacology, Gifu College of Pharmacy

• Nagai Hiroichi

  Department Of Clinical Pharmacology Gifu Pharmaceutical University

• Miura Toru

  Pharmaceutical Development Laboratory And Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.

• Xu Q

  Nanotechnology Research Institute National Institute Of Advanced Industrial Science And Technology (

• Xu Qiang

  Department Of Chemical Engineering Tsinghua University

• Koda Akihide

  Department Of Pharmacology Gifu College Of Pharmacy

• Matsuyama Toshifumi

  Pharmaceutical Development Laboratory And Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.

• OHIRA Kenji

  Department of Pharmacology, Gifu Pharmaceutical University

• Xu Q

  Nanotechnology Research Institute National Institute Of Advanced Industrial Science And Technology (

• Miura Toru

  Department Of Biology Graduate School Of Arts And Sciences University Of Tokyo

• Inagaki Naoki

  Departmen T Of Pharmacology Gifu Pharmaceutical University

• Inagaki Naoki

  Immunopharmacology Field Of Biofunctional Control Medical Information Science Division United Graduate School Of Drug Discovery And Medical Information Sciences Gifu University

• Nagai Hiroichi

  Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama

• Xu Qiang

  Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

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