Effect of Protease-Activated Receptor-2 Deficiency on Allergic Dermatitis in the Mouse Ear
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概要
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To investigate the involvement of protease-activated receptor-2 (PAR-2) in allergic dermatitis, we generated PAR-2-deficient (PAR-2−/−) mice. Ear thickness, contact hypersensitivity (CH) induced by topical application of picryl chloride (PC) or oxazolone (Ox) after sensitization, and vascular permeability after ear passive cutaneous anaphylaxis (PCA) were compared between wild-type (WT) and PAR-2−/− mice. Ear thickness was almost the same in untreated WT and PAR-2−/− mice. Topical application of PC or Ox thickened the ears at 6, 24 and 48 h after challenge with a peak at 24 h in WT mice. In PAR-2−/− mice, the ear swelling induced by both PC and Ox was suppressed at every time point, and significant inhibition was found at 24 h in PC-induced CH and at 24 and 48 h in Ox-induced CH. Histopathological observation of the ears at 24 h after challenge revealed that PC- or Ox-induced ear edema and infiltration of inflammatory cells in WT mice were greatly attenuated in PAR-2−/− mice. The vascular permeability in the ears after PCA was not different between WT and PAR-2−/− mice. These results strongly suggest that PAR-2 plays a crucial role in type IV allergic dermatitis but not in type I allergic dermatitis.
- 社団法人 日本薬理学会の論文
- 2002-01-01
著者
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WADA Yasushi
Tokyo Research Laboratories, Kowa Company Ltd.
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Wada Yasushi
Tokyo Research Laboratories Pharmaceutical Division Kowa Company Ltd
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Takizawa Toshiaki
Tokyo New Drug Research Laboratories Ii Pharmaceutical Division Kowa Company Ltd.
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Takizawa Toshiaki
興和
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Takizawa Toshiaki
岐阜薬科大学 薬理
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KANKE Toru
Tokyo New Drug Research Laboratories, Kowa Company Limited
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TAMIYA Masaki
Tokyo New Drug Research Laboratories II, Pharmaceutical Division, Kowa Company Ltd.
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MATSUMOTO Jiro
Tokyo New Drug Research Laboratories II, Pharmaceutical Division, Kowa Company Ltd.
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SAITO Naohiro
Tokyo New Drug Research Laboratories II, Pharmaceutical Division, Kowa Company Ltd.
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KAWAGOE Junichi
Tokyo New Drug Research Laboratories II, Pharmaceutical Division, Kowa Company Ltd.
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E. MEEK
Centre for Genome Research, The University of Edinburgh
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J. H.
Centre for Genome Research, The University of Edinburgh
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D. HUNTER
Department of Physiology and Pharmacology, University of Strathclyde, Stratheclyde Institute for Bio
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PLEVIN Robin
Department of Physiology and Pharmacology, University of Strathclyde, Stratheclyde Institute for Bio
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FUJII Mikio
Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company Ltd
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Kanke Toru
興和
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Kanke Toru
Tokyo New Drug Research Laboratories Ii Pharmaceutical Division Kowa Company Ltd.
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Matsumoto Jiro
Tokyo New Drug Research Laboratories Ii Pharmaceutical Division Kowa Company Ltd.
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Kawagoe Junichi
Tokyo New Drug Research Laboratories Ii Pharmaceutical Division Kowa Company Ltd.
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Kawagoe Junichi
興和東京研究所
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Tamiya M
Tokyo New Drug Research Laboratories Ii Pharmaceutical Division Kowa Company Ltd.
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Tamiya Masaki
興和東京研究所
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Saito Naohiro
Tokyo New Drug Research Laboratories Ii Pharmaceutical Division Kowa Company Ltd.
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Saito Naohiro
興和東京研究所
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Plevin Robin
興和東京研究所
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Plevin Robin
Department Of Physiology And Pharmacology University Of Strathclyde Stratheclyde Institute For Biome
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E. Meek
Centre For Genome Research The University Of Edinburgh
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Wada Yasushi
Tokyo Research Laboratories Kowa Co. Ltd.
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Tamiya Masaki
Tokyo New Drug Research Laboratories Ii Pharmaceutical Division Kowa Company Ltd.
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Fujii Mikio
Tokyo Research Laboratories Kowa Co. Ltd.
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Fujii Mikio
Tokyo Research Laboratories Pharmaceutical Division Kowa Company Ltd
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J. H.
Centre For Genome Research The University Of Edinburgh
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D. Hunter
Department Of Physiology And Pharmacology University Of Strathclyde Stratheclyde Institute For Biome
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