Ribosomal Protein S3 Immunoreactivity in the Young, Adult and Aged Gerbil Hippocampus
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概要
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Ribosomal protein S3 (rpS3) is well known to participate in DNA repair mechanisms. In the present study, we compared rpS3 immunoreactivity and its protein levels in the hippocampus among young, adult and aged gerbils. In the postnatal month (PM) 3 group as the young, rpS3 immunoreaction was observed in pyramidal and non-pyramidal cells of the hippocampus proper and in granule and polymorphic cells of the dentate gyrus. In the PM 12 group as adult and 24 group as the aged, rpS immunoreactivity in the hippocampus was decreased compared to the PM 3 group. Western blot analysis showed that rpS3 levels were decreased with time; lowest at PM 24. These results indicate that rpS3 immunoreactivity and protein levels were markedly decreased in the aged gerbil hippocampus.
著者
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Hwang In
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Choi Soo
Department Of Advanced Materials Engineering (polymerics Program) Korea Advanced Institute Of Scienc
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Choi Jung
Department Of Agricultural Biotechnology Seoul National University
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WON Moo-Ho
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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WON Moo-Ho
Department of Neurobiology, School of Medicine, Kangwon National University
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YOO Ki-Yeon
Institute of Natural Medicine, Hallym University
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CHOI Soo
Department of Biomedical Sciences and Research Institute for Bioscience and Biotechnology, Hallym University
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LEE Choong
Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Seoul National University
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