Neuronal Degeneration and Microglial Activation in the Ischemic Dentate Gyrus of the Gerbil
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概要
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In the present study, we investigated the time-course changes of neuronal degeneration and microglial activation in the gerbil dentate gyrus after transient cerebral ischemia using Fluoro-Jade B histofluorescence staining and immunohistochemistry for Iba-1. Fluoro-Jade B positive cells were observed from 6 hr and markedly increased 1 day after ischemia/reperfusion. Iba-1-immunoreactive microglia were increased and hypertrophied at early time, and Iba-1 immunoreactivity was highest at 2 days after ischemia/reperfusion. These results may be direct evidence on neuronal degeneration and microglial activation in the gerbil dentate gyrus after ischemia/reperfusion.
- 社団法人 日本獣医学会の論文
著者
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HWANG In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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CHOI Jung
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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YOO Ki-Yeon
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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LEE Choong
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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WON Moo-Ho
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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Hwang In
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee Choong
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Choi Jung
Department Of Anatomy And Neurobiology College Of Medicine Hallym University
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PARK Chan
Department of Anatomy, College of Medicine, Kyung Hee University
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SHIN Hyung-Cheul
Department of Physiology, College of Medicine, Hallym University
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MOON Joong
Department of Emergency Medicine, College of Medicine, Kangwon National University
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CHO Jun
Department of Emergency Medicine, College of Medicine, Kangwon National University
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Yoo Ki-yeon
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Park Chan
Department Of Anatomy College Of Medicine Kyung Hee University
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Choi Jung
Department Of Agricultural Biotechnology Seoul National University
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LEE Choong
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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WON Moo-Ho
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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PARK Chan
Department of Emergency Medicine, College of Medicine, Kangwon National University
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Cho Jun
Department of Chemical Engineering, Nagoya University
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