DA-9601 Decreases Immediate-Type Allergic Reaction and Tumor Necrosis Factor-α Production
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概要
- 論文の詳細を見る
The immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic disease is a very important subject in human health. The formulated ethanol extract of Artemisia asiatica Nakai (DA-9601) has been reported to have anti-oxidative and anti-inflammatory activities. In this report, we investigated the effect of DA-9601 on the immediate-type allergic reaction and studied its possible mechanisms of action, focusing on the mast cell-mediated allergic reaction. DA-9601 inhibited compound 48/80-induced systemic anaphylactic reactions and serum histamine release in mice. DA-9601 decreased the IgE-mediated passive cutaneous anaphylaxis, the model of local allergic reaction in vivo. DA-9601 dose-dependently reduced histamine release from mast cells activated by compound 48/80 or IgE. Furthermore, DA-9601 decreased the gene expression and production of tumor necrosis factor (TNF)-α in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. These findings provide evidence that DA-9601 could be a candidate as an anti-allergic agent.
- 公益社団法人日本薬学会の論文
- 2006-08-01
著者
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Kim Sang-hyun
Department Of Internal Medicine Cardiovascular Center Seoul National University Hospital:seoul Natio
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KIM Cheorl-Ho
Department of Biological Science, Sungkyunkwan University and National Research Laboratory for Glyco
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Lee Soyoung
韓国
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Park Hyo-hyun
Department Of Pharmacology School Of Medicine Kyungpook National University
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Kim Sang-hyun
韓国
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Park Won-hwan
韓国
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CHUNG JAE
Department of Internal Medicine, Division of Gastroenterology, Yonsei University College of Medicine
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Chung Jae
Department Of Biological Sciences Kaist
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Chung Jae
Department Of Emergency Medicine Kyungpook National University Hospital
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Kim Cheorl-ho
韓国
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Kim Cheorl-ho
Department Of Agricultural Chemistry The University Of Tokyo
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Kim Sug-Hyun
Department of Pharmacology, School of Medicine, Kyungpook National University
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Lee Soyoung
Department of Pharmacology, School of Medicine, Kyungpook National University
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Moon Jin-Young
Cardiovascular Medical Research Center and Dept. of AM-Pointology & Diagnostics, Dongguk University
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Park Won-Hwan
Cardiovascular Medical Research Center and Dept. of AM-Pointology & Diagnostics, Dongguk University
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Oh Tae-Young
Dong-A Pharmaceutical Research Institute
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Jun Chang-Duk
Department of Life Science, Gwangju Institutive of Science and Technology
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Moon Jin-young
Cardiovascular Medical Research Center And Dongguk University College Of Oriental Medicine
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Jun Chang-duk
Department Of Life Science Gwangju Institutive Of Science And Technology
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Lee Soyoung
Department Of Pharmacology School Of Medicine Kyungpook National University
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Kim Sang-hyun
Department Of Anesthesiology And Pain Medicine University Of Soonchunhyang Bucheon Hospital
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