Action of Dracocephalum argunense on Mast Cell-Mediated Allergy Model(Pharmacognosy)

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概要

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• The discovery of drugs for the treatment of allergic disease is an important subject in human health. Stimulation of mast cells starts the process of degranulation resulting in releasing of mediators, such as histamine. In this report, we investigated the effect of aqueous extract of Dracocephalum argunense FISCH. (Labiatae) (DAAE) on the mast cell-mediated allergic response and studied its possible mechanisms of action, focusing on the histamine release and pro-inflammatory cytokine secretion in mast cells. DAAE inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. In addition, DAAE attenuated IgE-mediated skin allergic reaction. DAAE dose-dependently reduced IgE-induced histamine release from mast cells. The level of cAMP was transiently increased by treatment of DAAE. DAAE specifically blocked the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-induced p38 mitogen-activated protein kinase (MAPK) activation. DAAE decreased the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6 in mast cells. Our findings provide evidence that DAAE inhibits mast cell derived allergic reactions, and involvement of cAMP for histamine release and p38 MAPK for pro-inflammatory cytokine secretion in these effects.

• 公益社団法人日本薬学会の論文
• 2006-03-01

著者

• Kim Sang-hyun

  Department Of Internal Medicine Cardiovascular Center Seoul National University Hospital:seoul Natio

• KIM Cheorl-Ho

  Department of Biological Science, Sungkyunkwan University and National Research Laboratory for Glyco

• SHIN Tae-Yong

  College of Pharmacy, Woosuk University

• Kim Sung-hwa

  College Of Pharmacy Sungkyunkwan University

• Kim Sang-hyun

  韓国

• Park Won-hwan

  韓国

• Kim Cheorl-ho

  韓国

• Kim Cheorl-ho

  Department Of Agricultural Chemistry The University Of Tokyo

• Kim Sug-Hyun

  Department of Pharmacology, School of Medicine, Kyungpook National University

• Moon Jin-Young

  Cardiovascular Medical Research Center and Dept. of AM-Pointology & Diagnostics, Dongguk University

• Park Won-Hwan

  Cardiovascular Medical Research Center and Dept. of AM-Pointology & Diagnostics, Dongguk University

• Moon Jin-young

  Cardiovascular Medical Research Center And Dongguk University College Of Oriental Medicine

• Shin Tae-yong

  College Of Pharmacy Woosuk University

• Kim Sang-hyun

  Department Of Anesthesiology And Pain Medicine University Of Soonchunhyang Bucheon Hospital

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