Re-Expression of Fetal Troponin Isoforms in the Postinfarction Failing Heart of the Rat
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概要
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Molecular switches between the troponin T and I isoforms are known to occur in various conditions, but the results from studies of failing human hearts with various etiologies are contradictory and it is not certain whether troponin isoform changes occur. Therefore, the molecular switching of troponin isoforms during normal development and heart failure (HF) after myocardial infarction were investigated in Sprague-Dawley rats at the fetal, neonate, and normal adult stages, and in a Postinfarction adult HF group. During normal development, switching from the fetal to the adult pattern of the troponin T and I isoforms was observed. Immunoblotting of postinfarction failing hearts revealed a marked increase in the fetal isoform of cardiac TnT (cTnT) (fetal/adult cTnT isoforms: normal adult=0 61+0 09 vs postinfarction HE= 1.59±0.13, p<0.001). Also, the amount of the adult troponin I (TnI) isoform decreased significantly in the postinfarction failing heart. In the semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) with glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) as an internal standard, the mRNA of fetal cTnT increased in the postinfarction failing heart (fetal cTnT/GAPDH: control= 0.22 vs HF rat= 0.84, p<O.05). Therefore, molecular switching of the troponin T and I isoforms occurred during the normal development of the rat, and there was re-expression of the fetal pattern of the isoforms in the postinfarction failing heart of the adult rat. (Circ J 2002; 66: 959-964)
- 社団法人日本循環器学会の論文
- 2002-09-20
著者
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Kim H‐s
Seoul National University Hospital
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Kim Hyo-soo
韓国
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Kim Hyo-soo
Seoul National University Hospital
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Kim Sang-hyun
Department Of Internal Medicine Cardiovascular Center Seoul National University Hospital:seoul Natio
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Kim Hyung-Kwan
Seoul National University Hospital
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Kang Hyun-jae
韓国
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Kang H‐j
Seoul National University Hospital
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KIM Hyo-Soo
Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital
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KIM Hyo-Soo
Jeju self-government province
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Lee Myoung-mook
Department of Internal Medicine
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Lee M‐m
Seoul National University Hospital
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Lee Myoung-mook
Division Of Cardiology Department Of Internal Medicine Seoul National University College Of Medicine
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Lee Myoung-mook
Department Of Internal Medicine Seoul National University College Of Medicine:cardiovascular Lab Cli
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Kim Hyo-soo
Cardiovascular Center And Department Of Internal Medicine Seoul National University Hospital
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Kim Sang-hyun
Department Of Anesthesiology And Pain Medicine University Of Soonchunhyang Bucheon Hospital
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