The 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor, Lovastatin (Statin) Ameliorates CCK-Induced Acute Pancreatitis in Rats(Pharmacology)
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概要
- 論文の詳細を見る
Statin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has an anti-inflammatory effect. The aim of this study was to investigate the effect of Lovastatin (statin) on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis in rats. In statin treated group, the pancreas weight/body weight (pw/bw) ratio in CCK-induced acute pancreatitis was significantly lower than DMSO-treated group. Statin also increased the pancreatic level of HSP 60. Additionally, the secretions of IL-1β, TNF-α and IL-6 and the lipase levels were decreased in statin treated group. These results suggest that statin may play an important role in mitigating the progression of the inflammatory reactions during acute pancreatitis.
- 社団法人日本薬学会の論文
- 2005-08-01
著者
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CHO Jeong
Department of Internal Medicine, Chonnam National University Hospital
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PARK Sung
Department of Material Science & Engineering, Gwangju Institute of Science and Technology
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Cho Jeong
Department Of Microbiology (bk21) College Of Medicine Kyung Hee University:kohwang Medical Research
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Cho Jeong-je
韓国
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SEO Sang-Wan
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University
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Ahn Hyun
Department Of Obstetrics And Gynecology College Of Medicine Catholic University Of Korea
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Ahn Hyun
Department Of Microbiology (bk21) College Of Medicine Kyung Hee University:kohwang Medical Research
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Park Cheung
Department Of Microbiology (bk21) College Of Medicine Kyung Hee University:kohwang Medical Research
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Seo S‐b
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University:department Of Oriental
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Seo Sang
Department Of Herbology College Of Oriental Medicine Wonkwang University
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CHOI Ok
Department of Microbiology, College of Medicine
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Park Cheung-seog
Department Of Microbiology College Of Medicine Kyung Hee University
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Choi Ok
Department Of Herbal Medicine College Of Natural Science Hoseo University
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Choi Ok
Department Of Microbiology College Of Medicine
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Cho Jeong-je
Department Of Microbiology College Of Medicine Kyung Hee University
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Park Sung
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University
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Park Sung
Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University
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Ahn Hyun
Department Of Anesthesiology And Pain Medicine Samsung Medical Center Sungkyunkwan University School
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Park Sung-joo
Department Of Herbology School Of Oriental Medicine Wonkwang University
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Choi Ok-Sun
Department of Microbiology, College of Medicine
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Seo Sang-Wan
Department of Herbology, College of Oriental Medicine, Wonkwang University
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Cho Jeong
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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