Safety Study of Yeast Hydrolysate with below 10 kDa Molecular Weight in Animal Models

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概要

• 論文の詳細を見る

• The aim of this study was to obtain data on the safety of yeast hydrolysate with below 10 kDa molecular weight. The acute [at a single dose of 5000 mg/kg body weight (BW)] and subacute (at a dose of 1000 mg/kg BW for 14 consecutive days) oral toxicity of yeast hydrolysate from Saccharomyces cerevisiae was assessed in Sprague-Dawley (SD) rats. The yeast hydrolysate acute treatment via the oral route at the dose of up to 5000 mg/kg did not produce any signs of toxicity or death in the rats. The yeast hydrolysate with below 10 kDa molecular weight did not induce any damage to the internal organs of the rats as examined by hematological and biochemical parameters. The macroscopic analysis of the treated animals did not show significant changes in color and texture. These results show that yeast hydrolysate with below 10 kDa molecular weight possesses very low toxicity as indicated in this SD rat model.

• 公益社団法人　日本薬学会の論文

著者

• Suh Hyung

  Department Of Food And Nutrition College Of Health Sciences Korea University

• Jung Eun

  Department Of Information And Communications Gwangju Institute Of Science And Technology

• Park Sung

  Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University

• Choi Jang

  Department of Bioindustry Daegu University

• Kim Jay

  Department of Food and Nutrition, Korea University

• Chang Un

  Department of Food and Nutrition, Dongduk Women's University

• Bae Song

  Department of Food and Biotechnology, Hankyong National University

• Chang Un

  Department of Food and Nutrition, Dongduk Women's University

• Jung Eun

  Department of Chemistry, Korea University, Seoul 136-701, Korea

• Suh Hyung

  Department of Food and Nutrition, Korea University

• Jung Eun

  Department of Food and Nutrition, Korea University

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