Cadmium Stimulates the Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) via p38 Mitogen-Activated Protein Kinase (MAPK) and JNK Activation in Cerebrovascular Endothelial Cells
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概要
- 論文の詳細を見る
In this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations of p38, JNK, and ERK. The Cd-induced VCAM-1 expression was significantly suppressed by either a specific p38 mitogen-activated protein kinase (MAPK) inhibitor (SB202190) or a JNK inhibitor (SP600125), but not by an ERK inhibitor (U0126). These results suggest that Cd induces the expression of VCAM-1, at least in part, via p38 and JNK pathways in bEnd.3 cells.
- 社団法人 日本薬理学会の論文
- 2009-07-20
著者
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PARK Sung
Department of Material Science & Engineering, Gwangju Institute of Science and Technology
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LEE Soo
Department of Environmental Engineering, Sun Moon University
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Moon Chang-hyun
Department Of Physiology Ajou University School Of Medicine
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BAIK Eun
Department of Physiology, School of Medicine, Ajou University
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JUNG Yi-Sook
Department of Physiology, School of Medicine, Ajou University
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Baik Eun
Department Of Physiology Ajou University School Of Medicine
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Lee Soo
Department Of Physiology Ajou University School Of Medicine
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KIM You-Mie
Department of Physiology, Ajou University School of Medicine
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AHN Jin-Hee
Department of Physiology, Ajou University School of Medicine
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Lee Soo
Department Of Chemistry (bk21) And Research Institute Of Natural Science Gyeongsang National Univers
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Ahn Jin-hee
Department Of Physiology Ajou University School Of Medicine
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Jung Yi-sook
Department Of Physiology Ajou University School Of Medicine
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Kim You-mie
Department Of Physiology Ajou University School Of Medicine
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Park Sung
Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University
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Park Sung
Department Of Physiology Ajou University School Of Medicine
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Lee Soo
Department Of Agricultural Chemistry The University Of Tokyo
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