KR-31466, a Benzopyranylindol Analog, Attenuates Hypoxic Injury Through Mitochondrial K_ATP Channel and Protein Kinase C Activation in Heart-Derived H9c2 Cells
スポンサーリンク
概要
- 論文の詳細を見る
In the present study, we investigated whether a novel benzopyranylindol analogue, KR-31466 (KR466) (1-[(2S,3R,4S)-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-2H-1-benzopyran-4-yl]-1H-indole-2-carboxylic acid ethyl ester) can attenuate hypoxic injury in heart-derived H9c2 cells and, if so, whether the protective effect of KR466 is mediated through mitochondrial ATP-sensitive potassium (mtKATP) opening. The treatment of H9c2 cells with KR466 (3 – 30 μM) significantly reduced hypoxia-induced cell death in a concentration-dependent manner, as shown by lactate dehydrogenase release and propidium iodide-uptake. In addition, KR466 (10 μM) significantly reduced the increase in hypoxia-induced TUNEL-positive cells, suggesting its anti-apoptotic potential in H9c2 cells. The protective effects of KR466 were abolished by 5-hydroxydecanoate, a specific blocker of the mtKATP channel, suggesting the involvement of the mtKATP channel in the protective effect of KR466. A specific inhibitor of protein kinase C (PKC), chelerythrine (3 μM), significantly attenuated the protective effect of KR466 against hypoxia-induced cardiac cell death. In conclusion, our results suggest that KR466 can protect H9c2 cells from hypoxia-induced death through mtKATP channel opening and PKC activation.
- 社団法人 日本薬理学会の論文
- 2003-05-01
著者
-
Kim M
Laboratory Of Hygienic Chemistry College Of Pharmacy Seoul National University
-
Moon Chang-hyun
Department Of Physiology Ajou University School Of Medicine
-
Kim Min
Laboratory Of Hygienic Chemistry College Of Pharmacy Seoul National University
-
JUNG Yoon
Department of Emergency Medicine, School of Medicine, Ajou University
-
Baik Eun
Department Of Physiology Ajou University School Of Medicine
-
Lee Soo
Department Of Physiology Ajou University School Of Medicine
-
Yoo Sung
Medical Science Division Korea Research Institute Of Chemical Technology
-
Kim Mi-young
Department Of Infectious Diseases College Of Veterinary Medicine Konkuk University
-
Lee Soo
Department Of Chemistry (bk21) And Research Institute Of Natural Science Gyeongsang National Univers
-
Yi Kyu
Medical Science Division Korea Research Institute Of Chemical Technology
-
Jung Yi-sook
Department Of Physiology Ajou University School Of Medicine
-
Kim M‐y
Ajou Univ. Suwon Kor
-
Yi Kyu
Bio-organic Sci. Div. Korea Res. Inst. Of Chemical Technol. Kor
-
Cho Joon
Department Of Ceramic Engineering Yonsei University
-
Cho Joon
Department Of Emergency Medicine School Of Medicine Ajou University
-
Lee Sunkyung
Medical Science Division Korea Research Institute Of Chemical Technology
-
Kim Min
Department Of Chemical Engineering Cheju National University
-
Lee Soo
Department Of Agricultural Chemistry The University Of Tokyo
-
Kim Min
Department of Applied Science, Korea Maritime University, Busan 606-791, Korea
-
KIM Min
Department of Animal Science and Biotechnology, College of Agriculture and Life Science, Chungnam National University, Daejeon 305–764, Korea
-
KIM Mi-Young
Department of Food and Nutrition, Chung-Ang University
-
JUNG Yi-Sook
Department of Pathophysiology, College of Pharmacy, Ajou University
関連論文
- Long-Term Clinical Course of Patients With Isolated Myocardial Bridge
- Preparation of functional metal nanoparticles embedded mullite composite powders by solid solution reduction
- Association of Tumor Necrosis Factor-α with Fever and Pulmonary Lesion Score in Pigs Experimentally Infected with Swine Influenza Virus Subtype H1N2
- 犬における胸骨への悪性大動脈小体腫瘍の異常転移(病理学)
- 1,2,3,4,6-Penta-O-galloyl-β-D-glucose Protects Splenocytes against Radiation-Induced Apoptosis in Murine Splenocytes
- 韓国における小児市中急性呼吸器感染症から分離した肺炎球菌に対するセフジトレンおよびその他の経口抗生物質の抗菌力
- Lack of Correlation Between QTc Dispersion and Morning Blood Pressure Surge in Recently Diagnosed Essential Hypertensive Patients
- Cloning and Heterologous Expression of a Ca^-Activated Chloride Channel Isoform from Rat Brain(Molecular and Cell Biology)
- Role of PKC-δ during Hypoxia in Heart-Derived H9c2 Cells
- High-Glucose Induced Protective Effect against Hypoxic Injury Is Associated with Maintenance of Mitochondrial Membrane Potential
- KR-31466, a Benzopyranylindol Analog, Attenuates Hypoxic Injury Through Mitochondrial K_ATP Channel and Protein Kinase C Activation in Heart-Derived H9c2 Cells
- Protein Kinase C Inhibitors Attenuate Protective Effect of High Glucose against Hypoxic Injury in H9c2 Cardiac Cells
- Cadmium Stimulates the Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) via p38 Mitogen-Activated Protein Kinase (MAPK) and JNK Activation in Cerebrovascular Endothelial Cells
- Protein Kinase C Inhibitors Abolish the Increased Resistance of Diabetic Rat Heart to Ischemia-Reperfusion Injury
- Thin-Layer Ablation of Metals and Silicon by Femtosecond Laser Pulses for Application to Surface Analysis
- P3-IS-73 Ruptured tubal pregnancy caused by inactive chorionic villi presenting with negative serum β-hCG(Group93 Reproduction3,International Session)
- P1-IS-79 Association studies of 5-HTT, DRD4 genes polymorphisms with fear during childbirth in Korean pregnant women
- P1-IS-54 Choledochal cyst diagnosed and conservatively treated during pregnancy
- P1-IS-53 Prenatal 3D-ultrasound diagnosis of Exencephaly associated with partial trisomy 2p and distal 5p deletion
- Myrothenones A and B, Cyclopentenone Derivatives with Tyrosinase Inhibitory Activity from the Marine-Derived Fungus Myrothecium sp.
- Fabrication of Polyaniline Silica Nanotubes and Closed Polyaniline Nanotubes Using a Template of Silica Nanotube
- Fluorescent Calix[4]arene-appended Silica Nanotubes as Selective Chemosensor and Adsorbent for Pb^ Ion
- Hydrogen Adsortion in Periodic Mesoporous Organic- and Inorganic-Silica Materials at Room Temperature
- Ultrastable Steroidal Nanotube Formed in Organic Solvents
- IS-50 TP 53 Restoration Using E6/E7 siRNA Potentiates Therapeutic Effect of Cisplatin in Cervical Squamous Cell Carcinoma(Group6 Oncology3,International Session)
- Aerobic Denitrification of Pseudomonas putida AD-21 at Different C/N Ratios(ENVIRONMENTAL BIOTECHNOLOGY)
- Serum Levels of Reproductive Hormones and Ultrasonographic Monitoring of Ovarian Follicles in Female Cloned Dogs
- Iron removal with phlebotomy and recombinant human erythropoietin in secondary hemochromatosis after allogeneic bone marrow transplantation
- Study on the Ophthalmic Diseases in ICR Mice and BALB/c Mice
- Spontaneous Ophthalmic Diseases in 586 New Zealand White Rabbits
- Fructose 1,6-Diphosphate Alleviates UV-Induced Oxidative Skin Damage in Hairless Mice(Pharmacology)
- N-Nitrosocarbofuran Induces Apoptosis in Mouse Brain Microvascular Endothelial Cells (bEnd.3)
- In vivoならびにIn vitroで成熟させた異なる生殖周期に採取した犬の卵母細胞中のグルタチオン濃度(臨床繁殖学)
- Influence of Irradiation Wavelength on Atomic Emission Spectroscopy Using Laser Ablation
- Ectopically Erupting First Permanent Molar in Chronic Myelogenous Leukemia
- Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts
- Systemic Inflammatory Syndrome and Hepatic Inflammatory Cell Infiltration Caused by an Interleukin-6 Producing Pheochromocytoma
- 犬の実験的慢性関節炎に対する刺針療法の有効性のサーモグラフィーによる評価(外科学)
- 正常犬の眼圧に対する刺針療法の効果(外科学)
- Reversal of Medetomidine-Ketamine Combination Anesthesia in Rabbits by Atipamezole
- Effect of increases in tumor volume after neoadjuvant chemotherapy on the outcome of stage II osteosarcoma regardless of histological response
- Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6
- IS-91 A case of perforated congenital colon atresia prenatally misdiagnosed as large lymphangioma(Group11 Perinatology3,International Session)
- P1-IS-95 Comparision of selective uterine artery ligation and blunt uterine artery coagulation in total laparoscopic hysterectomy
- Cardioprotective Effects of KR-30450, a Novel K^+_ Opener, and Its Major Metabolite KR-30818 on Isolated Rat Hearts
- Developmental Dental Complications during Anticancer Therapy in Children
- Influence of Thermal Stress on Quality Factor of the Layered Mg_Ca_TiO_3-(Ca_Li_Sm_)TiO_3 System Prepared by Spark Plasma Sintering
- Influence of Thermal Stress on Loss Quality of Mg_Ca_TiO_3-(Ca_Lio_Sm_)TiO_3 System at Microwave Frequencies
- A Novel Imidazo[1,5-b]isoquinolinone Derivative, U63A05, Inhibits Syk Activation in Mast Cells to Suppress IgE-Mediated Anaphylaxis in Mice
- A Finite Annular Plate Element with Slight Deviation for Vibration Analysis of a Nearly Axisymmetric Disk
- Study of Transport and Dielectric of Resistive Memory States in NiO Thin Film
- B208 ESTIMATION OF SPATIALLY VARYING THERMAL CONDUCTIVITY WITHOUT INTERNAL MEASUREMENTS(Gas turbine & forced convection heat transfer)
- FM-P10 Involvement of rpoE in starvation stress response of Lactobacillus fermentum MS79(Section VIII Fermentation and Microbial Technology)
- Determination of Fecal Shedding Rates and Genotypes of Swine Hepatitis E Virus (HEV) in Korea(Virology)
- Molecular Recognition of Organic Ammonium Ions by Diaza0Crown Ether-Modified β-Cyclodextrin in Aqueous Media
- Calcinosis cutis in systemic lupus erythematosus : A case report and review of the published work
- Role of UGT1A1^*6, UGT1A1^*28 and ABCG2 c.421C>A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients
- P1-IS-75 Third trimester umbilical artery Doppler velocimetry in twins to predict adverse perinatal outcome based on systolic/diastolic ratio difference
- Recurrence Rate of Lumbar Disc Herniation After Open Discectomy in Active Young Men
- Crystalline Silicon Solar Cells for Commercialization
- In Vitro Generation of Functional Dendritic Cells from Human Umbilical Cord Blood CD34^+ Cells by a 2-Step Culture Method
- Can γ-Glutamyltransferase be an Additional Marker of Arterial Stiffness?
- ISO-4 Criteria for the Safety of Less Radical Trachelectomy in Early-stage Cervical Cancer : a Multi-center Study(Group1 Oncology,International Session : Oral Presentation)
- Transport Correlation of Double-Diffusive Convection in Darcy-Extended Porous Layer
- Photoluminescence Studies of Porous ZnO Nanorods
- Identification of Caspase-Independent PKCε-JNK/p38 MAPK Signaling Module in Response to Metabolic Inhibition in H9c2 Cells
- ISO-3 The Influences of Surgical Stress on Ovarian Carcinoma Growth in an Animal Model: Laparoscopy vs. Laparotomy(Group1 Oncology,International Session : Oral Presentation)
- CR229, a novel derivative of β-carbolin-1-one, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation
- Cell cycle arrest and apoptotic induction in LNCaP cells by MCS-C2, novel cyclin-dependent kinase inhibitor, through p53/p21^ pathway
- Enzymatic Resolution of Racemic Ibuprofen Esters : Effects of Organic Cosolvents and Temperature
- Pasteurized autograft-prosthesis composite for distal femoral osteosarcoma
- Emulsifying Properties of Peptides Obtained from the Hydrolyzates of β-Casein(Food & Nutrition)
- Enzymatic Resolution of Racemic Ibuprofen by Lipase-Catalyzed Esterification Reaction : Effects of Water Content and Solid Supports
- Sclerosing hemangioma, presenting as a pneumonic pattern with mucinous adenomatous hyperplasia of the lung
- Chronic myeloid leukemia patient manifesting fatal hepatitis B virus reactivation during treatment with imatinib rescued by liver transplantation : case report and literature review
- Post-Transplant Lymphoproliferative Disorder Localized in the Colon After Liver Transplantation : Report of a Case
- FM-P8 Species prevalence and stress response of Lactobacillus spp. isolated from oyster(Section VIII Fermentation and Microbial Technology)
- Quench and Recovery Test on Stacked YBCO-Coated Conductors by Applying Various Intermediate Inserting Materials
- Purification and characterization of a D-mannose specific lectin from the green marine alga, Bryopsis plumosa
- Occult thyroid carcinoma detected by FDG-PET scan in elderly osteosarcoma patients : report of two cases
- Two cases of palmoplantar lichen planus with various clinical features
- Castleman's Disease of the Mesorectum : Report of a Case
- Identification of Interleukin-1, Tumor Necrosis Factor-α, and Interleukin-6 Expression in Lungs from Pigs Naturally Infected with Mycoplasma hyopneumoniae by In situ Hybridization
- Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer
- Multidrug-resistant Acinetobacter meningitis in a 3-year-old boy treated with i.v. colistin
- Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of goserelin in rabbit plasma
- Influence of Kinesio Taping on the Motor Neuron Conduction Velocity
- Effect of retinoic acid on renal development in newborn mice treated with an angiogenesis inhibitor
- Post-Stroke Rehabilitation Intervention : Effect of Spinal Stabilization with Visual Feedback on the Mobility of Stroke Survivors
- Antiphospholipid Syndrome Associated with Progressive Systemic Sclerosis
- Antimicrobial resistance in community-acquired urinary tract infections : results from the Korean Antimicrobial Resistance Monitoring System
- Overexpression of Galectin-3 and its clinical significance in ovarian carcinoma
- KR-31466, a Benzopyranylindol Analog, Attenuates Hypoxic Injury Through Mitochondrial K_ATP Channel and Protein Kinase C Activation in Heart-Derived H9c2 Cells
- Intersection of harmonics and Capelli identities for symmetric pairs
- 66. AtDWARF1 catalyzes 24-reduction of 24-methylene brassinosteroids to 24-methyl brassinosteroids in A. thaliana
- A Novel Imidazo[1,5-b]isoquinolinone Derivative, U63A05, Inhibits Syk Activation in Mast Cells to Suppress IgE-Mediated Anaphylaxis in Mice
- Two-Phase S-Clause Segmentation(Natural Language Processing)
- Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs
- Neural Stem Cells Modified by a Hypoxia-Inducible VEGF Gene Expression System Improve Cell Viability under Hypoxic Conditions and Spinal Cord Injury
- Determination of Fecal Shedding Rates and Genotypes of Swine Hepatitis E Virus (HEV) in Korea