Can γ-Glutamyltransferase be an Additional Marker of Arterial Stiffness?
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概要
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Background It has been recently suggested that γ-glutamyltransferase (GGT) is independently associated with cardiovascular mortality and atherosclerosis, so the present study evaluated whether GGT is an additional marker of arterial stiffness, independent of other risk factors, in screening cohorts. Methods and Results The 1,387 individuals (741 men, 646 women) who underwent brachial-ankle pulse wave velocity (baPWV) measurement had their serum levels of GGT, creatinine, uric acid, C-reactive protein, lipids, fasting glucose and insulin, and their hepatitis profiles checked. There were statistically significant increments of baPWV according to quartile of GGT, which was statistically significant in women, but not in men. In logistic regression analysis, age, diabetes mellitus, GGT, heart rate, history of hypertension, triglyceride, and systolic blood pressure were significant variables that influenced increased pulse wave velocity (PWV). After age- and blood pressure-adjustment, GGT, homeostatic model assessment-insulin resistance, heart rate, history of hypertension, and metabolic syndrome were significant variables in men, and in women metabolic syndrome and history of hypertension were significant contributors to increased PWV. Conclusion The present study results suggest that serum GGT may be an additional marker of arterial stiffness, especially in men, though the relationship with arterial stiffness was very weak. Further studies are needed to elucidate the mechanism of GGT's contribution to arteriosclerosis and to confirm the current results. (Circ J 2007; 71: 1715-1720)
- 社団法人日本循環器学会の論文
- 2007-10-20
著者
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LEE Soo
Department of Environmental Engineering, Sun Moon University
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KIM Yun
Department of wind engineering, Hyundai Institute of Construction Technology
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Lee Dong
Department Of Environmental Atmospheric Science Pukyong National University
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Lee Bong
Department Of Anatomy And Neurobiology College Of Medicine Institute Of Medical Science Cheju Nation
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Kim Seong-jang
Department Of Nuclear Medicine Pusan National University Hospital
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Kim Seong-jang
韓国
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Kim Yun
Medical Research Institute Pusan National University Hospital
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Song Sang
Medical Research Institute Pusan National University Hospital
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Lee Soo
Department Of Chemistry (bk21) And Research Institute Of Natural Science Gyeongsang National Univers
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Lee Dong
Department Of Biotechnology College Of Natural Science Dongguk University
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Kim Yun
Department Of Chemistry Korea Advanced Institute Of Science & Technology
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Lee Dong
Department Of Internal Medicine Pusan National University Hospital
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SONG SANG
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine
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Kwak Ihm
Medical Research Institute Pusan National University Hospital
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KWAK Ihm
Department of Internal Medicine, Pusan National University Hospital
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Song Sang
Department Of Diagnostic Pathology Samsung Medical Center Sungkyunkwan University School Of Medicine
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Lee Dong
Department Of Aerospace Engineering Chonbuk National University
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Lee Soo
Medical Research Institute Pusan National University
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Lee Bong
Department Of Internal Medicine:department Of Medical Research Institute Pusan National University H
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Lee Soo
Department Of Agricultural Chemistry The University Of Tokyo
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